Influenza A and respiratory syncytial virus hospital burden in young children in East London

Ajayi-Obe, E. K.; Coen, Pietro G.; Handa, Rahul; Hawrami, Khidir; Aitken, Celia; McIntosh, E. David G.; Booy, Robert

doi:10.1017/s0950268807009557

Cited by 20 publications

(11 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirdly, it is possible that age‐related differences in testing practices may have impacted our quantitative estimates—particularly those for influenza‐associated admissions. However, that our results demonstrate a significantly higher burden of RSV‐associated hospital admissions in young children compared to other respiratory pathogens , including influenza, is consistent with the results of previous studies 16, 17, 18. Finally, as we restricted hospital admissions to those with a primary diagnosis of URTI or LRTI, our results are likely to be an underestimate of the true burden of RSV‐associated hospital admissions.…”

Section: Discussionsupporting

confidence: 91%

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Reeves

Hardelid

Gilbert

et al. 2017

Influenza Resp Viruses

101

View full text Add to dashboard Cite

BackgroundRespiratory syncytial virus (RSV) is a leading cause of hospital admission in young children. With several RSV vaccines candidates undergoing clinical trials, recent estimates of RSV burden are required to provide a baseline for vaccine impact studies.ObjectivesTo estimate the number of RSV‐associated hospital admissions in children aged <5 years in England over a 5‐year period from 2007 using ecological time series modelling of national hospital administrative data.Patients/MethodsMultiple linear regression modelling of weekly time series of laboratory surveillance data and Hospital Episode Statistics (HES) data was used to estimate the number of hospital admissions due to major respiratory pathogens including RSV in children <5 years of age in England from mid‐2007 to mid‐2012, stratified by age group (<6 months, 6‐11 months, 1‐4 years) and primary diagnosis: bronchiolitis, pneumonia, unspecified lower respiratory tract infection (LRTI), bronchitis and upper respiratory tract infection (URTI).ResultsOn average, 33 561 (95% confidence interval 30 429‐38 489) RSV‐associated hospital admissions in children <5 years of age occurred annually from 2007 to 2012. Average annual admission rates were 35.1 (95% CI: 32.9‐38.9) per 1000 children aged <1 year and 5.31 (95% CI: 4.5‐6.6) per 1000 children aged 1‐4 years. About 84% (95% CI: 81‐91%) of RSV‐associated admissions were for LRTI. The diagnosis‐specific burden of RSV‐associated admissions differed significantly by age group.Conclusions RSV remains a significant cause of hospital admissions in young children in England. Individual‐level analysis of RSV‐associated admissions is required to fully describe the burden by age and risk group and identify optimal prevention strategies.

show abstract

Section: Discussionsupporting

confidence: 91%

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Reeves

Hardelid

Gilbert

et al. 2017

Influenza Resp Viruses

101

View full text Add to dashboard Cite

show abstract

“…This was followed by RSV which was only isolated in patients with LRTI and in the 1-12 month age cluster. This is similar to other studies which showed that RSV is major cause of LRTI (Ajayi-Obe et al, 2008;Van Woensel et al, 2003). There are differences in the proportions of virus isolates when this study is compared to the study carried out by Hazlett et al (1998).…”

supporting

confidence: 92%

Prevalence of viral aetiologies in children with acute respiratory infections in Nairobi, Kenya

Symekher¹,

Ochieng²,

Simwa³

2009

Tanzania J Hlth Res

View full text Add to dashboard Cite

Acute respiratory infections (ARIs) are among the leading causes of morbidity and mortality in children under five years in developing countries. Viruses have been long established to be causes of ARIs, but there is little information in developing countries especially Africa. This cross-sectional study was carried out in April-July 2008 in Nairobi, Kenya aiming at establishing which virus isolates and what age cluster in children with ARIs are affected. Throat swabs were collected from patients with clinical ARI and inoculated to various cell lines to isolate and identify viruses. A total of 388 children (age range = 1-132 months) were recruited. Of these 210 (54.1%) were males and 178 (45.9%) were females. Twenty-six percent (101) had upper (URTI) while 74% (287) had lower (LRTI) respiratory tract infections. There were 177 (45.6%) viruses isolated; adenovirus (27; 7%), parainfluenza (25; 6.4%), influenza (20; 5.2%), respiratory syncytial virus (19; 4.9%) and unidentified viruses (86; 22.2%). Majority of the viruses were isolated from patients with LRTI (110; 28.4%) while URTI had 67 (17.3%) isolates. The age cluster 1-12months (105; 27.1%) followed by 13-24months (36; 9.3%) had majority of the viral isolates. Thus this study indicates that viruses are associated with ARIs in children 1-2years of age and therefore a longitudinal study with sensitive virus detection methods is required to provide more information on the precise disease burden and magnitude of the problem. ________________________________________________________________________________

show abstract

“…Hospitalization rates for RSV ARIs increase with decreasing age, peaking in the first few months of life [ 4 , 6 , 7 , 16 , 34 , 35 , 37 , 56 , 61 ]. Most retrospective studies have consistently shown RSVH to be the highest in the first year of life [ 7 , 49 , 56 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

Defining the Epidemiology and Burden of Severe Respiratory Syncytial Virus Infection Among Infants and Children in Western Countries

et al. 2016

View full text Add to dashboard Cite

IntroductionThe REGAL (RSV [respiratory syncytial virus] Evidence—a Geographical Archive of the Literature) series provides a comprehensive review of the published evidence in the field of RSV in Western countries over the last 20 years. This first of seven publications covers the epidemiology and burden of RSV infection.MethodsA systematic review was undertaken for articles published between Jan 1, 1995 and Dec 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov. Studies reporting data for hospital visits/admissions for RSV infection among children (≤18 years of age), as well as studies reporting RSV-associated morbidity, mortality, and risk factors were included. Study quality and strength of evidence (SOE) were graded using recognized criteria.Result2315 studies were identified of which 98 were included. RSV was associated with 12–63% of all acute respiratory infections (ARIs) and 19–81% of all viral ARIs causing hospitalizations in children (high SOE). Annual RSV hospitalization (RSVH) rates increased with decreasing age and varied by a factor of 2–3 across seasons (high SOE). Studies were conflicting on whether the incidence of RSVH has increased, decreased, or remained stable over the last 20 years (moderate SOE). Length of hospital stay ranged from 2 to 11 days, with 2–12% of cases requiring intensive care unit admission (moderate SOE). Case-fatality rates were <0.5% (moderate SOE). Risk factors associated with RSVH included: male sex; age <6 months; birth during the first half of the RSV season; crowding/siblings; and day-care exposure (high SOE).ConclusionRSV infection remains a major burden on Western healthcare systems and has been associated with significant morbidity. Further studies focusing on the epidemiology of RSV infection (particularly in the outpatient setting), the impact of co-infection, better estimates of case-fatality rates and associated risk factors (all currently moderate/low SOE) are needed to determine the true burden of disease.FundingAbbvie.Electronic supplementary materialThe online version of this article (doi:10.1007/s40121-016-0123-0) contains supplementary material, which is available to authorized users.

show abstract

Influenza A and respiratory syncytial virus hospital burden in young children in East London

Cited by 20 publications

References 44 publications

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Prevalence of viral aetiologies in children with acute respiratory infections in Nairobi, Kenya

Defining the Epidemiology and Burden of Severe Respiratory Syncytial Virus Infection Among Infants and Children in Western Countries

Contact Info

Product

Resources

About