Influenza A(H1N1)pdm09 virus and asthma

Abstract

Respiratory viral infection is a major cause of asthma exacerbations in both children and adults. Among the respiratory viruses, influenza virus is a particularly important pathogen due to its enormous morbidity and mortality in annual epidemics. The swine-origin influenza A virus, designated as A(H1N1)pdm09, emerged in the spring of 2009 and caused the first influenza pandemic in the 21st century. With the emergence of the novel A(H1N1)pdm09 virus, numerous epidemiologic studies detected asthma as a frequent comorbid condition in patients infected with this virus. Here we review recent reports regarding asthma in patients infected with influenza A(H1N1)pdm09 virus, and we discuss the utility of influenza vaccines and antivirals.

Mast Cells and Influenza A Virus: Association with Allergic Responses and Beyond

“…These upper respiratory tract infections frequently lead to hospital admission for asthma patients (97). Interestingly, asthma was the most common comorbidity among hospitalized patients during the 2009 H1N1pdm IAV pandemic (98)(99)(100)(101). A state of hyperresponsiveness in the asthmatic patients, as well as increased levels of inflammatory molecules (e.g., histamine, IL-6, and leukotriene), are believed to contribute to asthmatic exacerbation from viral infection (102).…”

Protective effects of influenza A (H1N1) pandemic 2009 vaccination against the onset of influenza-like illness and asthma exacerbation in Japanese children

“…Moreover, consecutive asthma exacerbation was also reduced in vaccinated children with asthma. Although the effectiveness of A(H1N1)pdm09 vaccines are widely reported [9][10][11][12], there are few reports that discuss the effectiveness in patients with asthma [19,44,45]. To our knowledge, ours is the first investigation to focus on differences in the effectiveness of vaccination for PDIA with mild to moderate ILI between children with and without asthma and consecutive asthma exacerbation related to influenza A(H1N1)pdm09 infection.…”

“…Kloepfer et al [16] showed that children with asthma had increased susceptibility for A(H1N1)pdm09 infection compared to children without asthma, which was concluded before widespread A(H1N1)pdm09 vaccine release to avoid confounding results with immunological effects of the virus and false positive test results resulting from use of the live virus vaccine. Although the effectiveness of A(H1N1)pdm09 vaccines are widely reported [9,10,, there are few reports that discuss the effectiveness in patients with asthma [19,44,45].…”

Research Advance in the Efficacy and Mechanism of Qing Fei Xiao Yan Wan for the Treatment of Respiratory Diseases

“…Respiratory viral infection is a major cause of "Asthma" and "Tissis" in both children and adults [32]. Among the respiratory viruses, influenzavirus is a particularly important pathogen due to its enormous morbidity and mortality in annual epidemics [33]- [35].…”