Influenza A (H1N1pdm09)-Related Critical Illness and Mortality in Mexico and Canada, 2014*

Domínguez-Cherit, Guillermo; Torre, Alethse de la; Rishu, Asgar; Pinto, Ruxandra; Ñamendys‐Silva, Silvio A.; Camacho-Ortíz, Adrián; Silva-Medina, Marco Antonio; Hernández-Cárdenas, Carmen Margarita; Martínez‐Franco, Michel; Quesada-Sánchez, Alejandro; López-Gallegos, Guadalupe Celia; Mosqueda, Juan L.; Rivera-Martinez, Norma E.; Campos-Calderón, Fernando; Rivero-Sigarroa, Eduardo; Hernández‐Gilsoul, Thierry; Espinosa-Pérez, Lourdes; Macías, Alejandro E.; Lue-Martínez, Dolores M.; Buelna-Cano, Christian; Luna, Ana-Sofía Ramírez-García; Cruz-Ruiz, Néstor G; Poblano-Morales, Manuel; Molinar-Ramos, Fernando; Hernández-Torre, Martín; León-Gutiérrez, Marco Antonio; Rosaldo-Abundis, Oscar; Baltazar-Torres, José Ángel; Stelfox, Henry T.; Light, Bruce; Jouvet, Philippe; Reynolds, Steve; Hall, Richard; Shindo, Nikki; Daneman, Nick; Fowler, Robert

doi:10.1097/ccm.0000000000001830

Cited by 22 publications

(15 citation statements)

References 16 publications

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“…Influenza pneumonia, caused by virulent strains of influenza A virus (IAV), remains a major global health problem with seasonal influenza epidemics and unexpected pandemics that have occurred for more than a century. For example, the virulent H1N1 strain of influenza identified in the 2009 flu pandemic caused increased morbidity and mortality worldwide ( 220 – 222 ). Patients admitted in intensive care unit (ICU) with severe influenza pneumonia usually presented acute lung injury and acute respiratory distress syndrome (ALI/ARDS) which have exacerbated immune response and increased systemic and airway inflammation as central features of pathogenesis ( 221 , 223 , 224 ).…”

Section: Platelet Activation In the Pathophysiology Of Viral Infectiomentioning

confidence: 99%

Platelets in Immune Response to Virus and Immunopathology of Viral Infections

2018

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Platelets are essential effector cells in hemostasis. Aside from their role in coagulation, platelets are now recognized as major inflammatory cells with key roles in the innate and adaptive arms of the immune system. Activated platelets have key thromboinflammatory functions linking coagulation to immune responses in various infections, including in response to virus. Recent studies have revealed that platelets exhibit several pattern recognition receptors (PRR) including those from the toll-like receptor, NOD-like receptor, and C-type lectin receptor family and are first-line sentinels in detecting and responding to pathogens in the vasculature. Here, we review the main mechanisms of platelets interaction with viruses, including their ability to sustain viral infection and replication, their expression of specialized PRR, and activation of thromboinflammatory responses against viruses. Finally, we discuss the role of platelet-derived mediators and platelet interaction with vascular and immune cells in protective and pathophysiologic responses to dengue, influenza, and human immunodeficiency virus 1 infections.

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Section: Platelet Activation In the Pathophysiology Of Viral Infectiomentioning

confidence: 99%

Platelets in Immune Response to Virus and Immunopathology of Viral Infections

2018

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“…A decade has passed since the 2009 H1N1 influenza pandemic which caused approximately 201,200 deaths due to respiratory diseases, principally pneumonia, and an additional 83,300 deaths due to cardiovascular diseases in the first year of the circulation of the virus. Significantly, most deaths occurred in young adults who often presented no comorbidities [49,50].…”

Section: The Role Of Pneumonia and Secondary Bacterial Infection In Tmentioning

confidence: 99%

Defining Community-Acquired Pneumonia as a Public Health Threat: Arguments in Favor from Spanish Investigators

et al. 2020

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Despite advances in its prevention, pneumonia remains associated with high morbidity, mortality, and health costs worldwide. Studies carried out in the last decade have indicated that more patients with community-acquired pneumonia (CAP) now require hospitalization. In addition, pneumonia management poses many challenges, especially due to the increase in the number of elderly patients with multiple comorbidities, antibiotic-resistant pathogens, and the difficulty of rapid diagnosis. In this new call to action, we present a wide-ranging review of the information currently available on CAP and offer some reflections on ways to raise awareness of this disease among the general public. We discuss the burden of CAP and the importance of attaining better, faster microbiological diagnosis and initiating appropriate treatment. We also suggest that closer cooperation between health professionals and the population at large could improve the management of this largely preventable infectious disease that takes many lives each year.

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“…This is a time-in-motion study accompanying a prospective surveillance project to assess the feasibility of screening and real-time data collection for severe acute respiratory infection (SARI)-and outbreak-related critical illness. The parent prospective study aimed to screen all hospitalized critically ill patients on a daily basis for up to 72 hours after admission to detect all cases of SARI, the details of which are published elsewhere [12]. The study included 1 pediatric and 5 adult intensive care units (ICUs) across 6 Canadian provinces.…”

Section: Design and Settingmentioning

confidence: 99%