Influenza A Pneumonia With Rhabdomyolysis

Morton, Steven E.; Mathai, Mathew; Byrd, Ryland P.; Fields, Cheryl L.; Roy, Thomas M.

doi:10.1097/00007611-200194010-00013

Cited by 17 publications

(9 citation statements)

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“…Since our patients were older than those in the previously reported study by Morton et al. (6) (mean age, 72.0 years and 54.3 years, respectively), it must be recognized that the S. epidermidis infection occurs not only due to pneumonia, but also due to rhabdomyolysis and ARF in immunocompromised hosts such as the elderly and alcoholics.…”

Section: Discussionmentioning

confidence: 54%

“…Acute renal failure can also occur after viral infections such as influenza, severe acute respiratory syndrome (SARS), and those due to the coronavirus (2)(3)(4)(5). It has been reported that bacterial and viral infections account for only 5% of rhabdomyolysis cases (6); therefore, it is not certain whether rhabdomyolysis-associated ARF is a result of the infectious diseases. However, pneumonia-associated rhabdomyolysis induces renal failure with a fatal outcome.…”

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confidence: 99%

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Clinical Evaluation of Pneumonia‐associated Rhabdomyolysis With Acute Renal Failure

2008

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This study aims to evaluate the clinical features, diagnosis, and treatment efficacy in patients with pneumonia-associated rhabdomyolysis and acute renal failure. The subjects included six patients who had presented with rhabdomyolysis and acute renal failure due to bacterial or viral pneumonia on admission to our university hospital and the Yokohama Social Insurance Central Hospital between 2004 and 2005. The causative organisms were identified as Legionella pneumophila (N = 1), Staphylococcus epidermidis (N = 2), Staphylococcus aureus (N = 1), and Unknown (N = 2). For anuric or oliguric patients (N = 4), a blood purification therapy was performed, while conservative therapy was administered to those with a normal urine volume (N = 2). The patient suffering from L. pneumophila pneumonia did not survive, while the other patients regained full kidney function. It is important to identify, evaluate, and treat patients with bacterial or viral pneumonia-associated rhabdomyolysis and acute renal failure.

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Section: Discussionmentioning

confidence: 54%

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confidence: 99%

Clinical Evaluation of Pneumonia‐associated Rhabdomyolysis With Acute Renal Failure

2008

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“…We found two spots that were expressed strongly in 2DE gels of co-infected samples, and identified the proteins as A1AT and CK by PMF analysis. The increase in CK may reflect the results of severe damage of the lung tissues, similar to myocardial muscles and skeletal muscles [13][14][15]. However, A1AT was considered to be a critical protein, as trypsin and trypsin-like proteases, such as tryptase Clara, are known to activate the infectivity of influenza virus [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…The detection of CK may simply be a reflection of lung tissue damage because of the severe pneumonia, as increased CK has been reported to result from severe myositis [13,14] and rhabdomyolysis [15]. However, A1AT was reported as a key molecule in the resolution of severe lung inflammation, including that associated with pneumonia and acute respiratory distress syndrome [16][17][18][19][20].…”

Section: Expression Of A1at In Co-infected Lungsmentioning

confidence: 99%

Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice

Kosai

Seki

Yanagihara

et al. 2008

Clinical and Experimental Immunology

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SummarySevere pneumonia is found in simultaneous influenza pneumonia and bacterial infection, and suggests a relationship with immunological mechanisms. Here, we performed two-dimensional gel electrophoresis to detect immunological molecules related to the fulminant pneumonia caused by influenza virus and Streptococcus pneumoniae co-infection in mice. We found two spots that were expressed strongly in co-infected mouse lungs, compared with S. pneumoniae or influenza virus singly infected mouse lungs. The spots were analysed by mass spectrometry, and identified as alpha-1 anti-trypsin (A1AT), known as an anti-protease for neutrophil-derived proteolytic enzymes, and creatine kinase, which reflects a greater degree of lung damage and cell death. A1AT expression was increased significantly, and proteolytic enzymes from neutrophils, such as neutrophil elastase, myeloperoxidase and lysozyme, were also secreted abundantly in influenza virus and S. pneumoniae co-infected lungs compared with S. pneumoniae or influenza virus singly infected lungs. These data suggest that A1AT may play a central role as a molecule with broad anti-inflammatory properties, and regulation of the neutrophil-mediated severe lung inflammation is important in the pathogenesis of co-infection with influenza virus and bacteria.

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“…Les données biologiques objectivaient une lymphopénie, une altération du bilan hépatique, des troubles de coagulation et une insuffisance rénale. Une rhabdomyolyse peut être observée en particulier chez le patient âgé, sans retentissement apparent sur le pronostic même si le nombre de cas décrits reste faible [40].…”

Section: Signes Cliniquesunclassified

Pneumonie virale sévère de l'immunocompétent

et al. 2004

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Reçu et accepté le 7 février 2004 RésuméLes infections virales respiratoires communautaires sont fréquentes et le plus souvent bénignes. Beaucoup d'agents différents comme les virus influenza, ou para-influenza, le virus respiratoire syncitial, les rhinovirus, coronavirus, adénovirus et les herpès virus peuvent être isolés chez les patients immunocompétents. Parmi ces virus, le cytomégalovirus (CMV) peut être responsable de pneumonie nosocomiale en réanimation. Le diagnostic des infections virales est difficile car les signes cliniques sont non spécifiques et l'isolement du virus responsable difficile. Cependant, une symptomatologie clinique associant fièvre, myalgies, céphalées, pharyngite est fréquente dans les infections à Inflenza qui peuvent aboutir à des tableaux sévères. Enfin, le virus plus récent responsable d'infection respiratoire est un virus nouvellement découvert de la famille des coronavirus, le SRAS-CoV qui a été responsable d'une épidémie d'infections respiratoires sévères. Les pneumonies virales sont fréquentes mais probablement non diagnostiquées chez les patients immunocompétents. Cependant le diagnostic est nécessaire car pour la plupart des pathogènes il existe un traitement efficace. Le diagnostic repose sur l'histologie mais de nouvelles techniques comme la PCR doivent devenir d'utilisation courante pour améliorer le rendement diagnostique. © 2004 Société de réanimation de langue française. Publié par Elsevier SAS. Tous droits réservés. AbstactRespiratory infections are frequently encountered in the community; these infections are usually associated with only minor consequences. Many different agents, such as influenza and parainfluenza virus, respiratory syncitial virus, rhinovirus, coronavirus, adenovirus and herpes virus can be found in immuno-competent patients. Among these pathogens, cytomegalovirus (CMV) has been found to be responsible for nosocomial pneumonia in ICU. The main problem for viral infections, is the diagnosis, isolation of the pathogen is often difficult and not always reliable and the symptoms not specific. However, influenza is characterised by fever, myalgia, headache and pharyngitis, this infection may be very mild, even asymptomatic, moderate or very severe. Finally, the most recent viral pathogen involved in respiratory disease is a newly discovered coronavirus, the SARS-CoV which was responsible for the worldwide outbreak of Severe Acute Respiratory Syndrome. Viral pneumonia is a common pathology which is probably underdiagnosed in immuno-competent patients; many reports show that even if the diagnosis is difficult to obtain, it is not useless as long as we have, for most of the pathogens, an effective treatment. The gold standard was histology, new techniques like PCR can probably make a difference and should be included in the guidelines to improve diagnostic efficiency. © 2004 Société de réanimation de langue française. Publié par Elsevier SAS. Tous droits réservés.

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Influenza A Pneumonia With Rhabdomyolysis

Cited by 17 publications

References 0 publications

Clinical Evaluation of Pneumonia‐associated Rhabdomyolysis With Acute Renal Failure

Clinical Evaluation of Pneumonia‐associated Rhabdomyolysis With Acute Renal Failure

Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice

Pneumonie virale sévère de l'immunocompétent

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