Influenza a Precipitating Multiorgan Failure Syndrome in Sickle Cell Disease

Duran, Crystal; Taskar, Varsha

doi:10.1016/j.chest.2018.08.259

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“…Hepatitis, myocarditis, and renal injury are well-known extrapulmonary manifestations of atypical pneumonia [12]. Severe influenza can also have a similar presentation with fever, myalgia, and type 1 respiratory failure with multiorgan dysfunction [13]. A diagnosis of hantavirus was considered due to the close resemblance of symptomatology with leptospirosis, although it is very infrequently reported [8].…”

Section: Discussionmentioning

confidence: 99%

Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report

Dalugama

Nanayakkara²,

Rathnayaka³

et al. 2020

J Med Case Reports

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Background Hantavirus infection is an emerging zoonotic infection which has two characteristic patterns of presentation: hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. The clinical presentation of hantavirus infection closely mimics leptospirosis. Case presentation This case report describes a previously apparently well 36-year-old Sri Lankan Sinhalese man who presented with an acute febrile illness with myalgia, with liver involvement in the form of transaminitis, cardiac involvement in the form of myocarditis, acute kidney injury, and pulmonary involvement. He was initially managed as severe leptospirosis with multiorgan dysfunction with antibiotics, steroids, and N-acetyl cysteine. A diagnosis of acute hantavirus infection was made subsequently. He made an uneventful recovery. Conclusion Hantavirus infections need to considered in the differential diagnosis of patients presenting with acute febrile illness with multiorgan involvement. Larger studies are needed to evaluate the seroprevalence of hantavirus in Sri Lanka because it could be an emerging serious public health problem.

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Section: Discussionmentioning

confidence: 99%