Influenza (A2/Hong Kong/68) in the Baboon (Papio sp.)

Kalter, S. S.; Heberling, R. L.; Vice, T. E.; Lief, Florence S.; Rodriguez, A. R.

doi:10.3181/00379727-132-34214

Cited by 24 publications

(6 citation statements)

References 3 publications

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“…Swine and Great Lake, 7.9%. Serological conversions occurred in experimentally infected (A2/Hong Kong/68) and noninfected control contact baboons (193). Heberling and Kalter (127) demonstrated that treatment of influenzainoculated baboons with poly-IC resulted in a delay or supression of antibody.…”

Section: Myxovirusesmentioning

confidence: 99%

Comparative virology of primates.

Kalter¹,

Heberling²

1971

Bacteriological Reviews

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1 WHO Collaborating Laboratory on Comparative Medicine: Simian Viruses. were listed by The Science Information Exchange of the Smithsonian Institution for fiscal year 1967 at a cost of approximately $55,000,000. Augmented usage of various monkeys and apes may be anticipated for the future, as evidenced by the yearly increase in numbers employed in an attempt to comply with requests by laboratories and by development of additional major primate research centers throughout the world. Breeding programs are anticipated to limit the numbers of animals eventually imported, but such efforts will 310

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Section: Myxovirusesmentioning

confidence: 99%

Comparative virology of primates.

Kalter¹,

Heberling²

1971

Bacteriological Reviews

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“…Kalter et al performed a study in yellow baboons ( Papio cynocephalus ), in which they challenged three animals IN with the recently emerged H3N2 virus, while three control animals were kept in adjoining cages (Kalter et al, 1969a). Two of the inoculated baboons developed low-grade fevers, and one appeared anorexic, but no other signs of disease were observed.…”

Section: Experimental Infections Of Nhps With Human Influenza VImentioning

confidence: 99%

The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893–2014

2015

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Attempts to reproduce the features of human influenza in laboratory animals date from the early 1890s, when Richard Pfeiffer inoculated apes with bacteria recovered from influenza patients and produced a mild respiratory illness. Numerous studies employing nonhuman primates (NHPs) were performed during the 1918 pandemic and the following decade. Most used bacterial preparations to infect animals, but some sought a filterable agent for the disease. Since the viral etiology of influenza was established in the early 1930s, studies in NHPs have been supplemented by a much larger number of experiments in mice, ferrets and human volunteers. However, the emergence of a novel swine-origin H1N1 influenza virus in 1976 and the highly pathogenic H5N1 avian influenza virus in 1997 stimulated an increase in NHP research, because these agents are difficult to study in naturally infected patients and cannot be administered to human volunteers. In this paper, we review the published literature on the use of NHPs in influenza research from 1893 through the end of 2014. The first section summarizes observational studies of naturally occurring influenza-like syndromes in wild and captive primates, including serologic investigations. The second provides a chronological account of experimental infections of NHPs, beginning with Pfeiffer’s study and covering all published research on seasonal and pandemic influenza viruses, including vaccine and antiviral drug testing. The third section reviews experimental infections of NHPs with avian influenza viruses that have caused disease in humans since 1997. The paper concludes with suggestions for further studies to more clearly define and optimize the role of NHPs as experimental animals for influenza research.

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“…Ohwada et al (260) Swine and Great Lake, 7.9%. Serological conversions occurred in experimentally infected (A2/Hong Kong/68) and noninfected control contact baboons (193). Heberling and Kalter (127) demonstrated that treatment of influenzainoculated baboons with poly-IC resulted in a delay or supression of antibody.…”

Section: Myxovirusesmentioning

confidence: 99%