Influenza Antibody Response Following Aerosal Administration of Inactivated Viruis1

Waldman, Robert H.; Wood, S. H.; Torres, Elisa; Small, Parker A.

doi:10.1093/oxfordjournals.aje.a121170

Cited by 91 publications

(32 citation statements)

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“…footpad injection) of a solu ble DNP antigen is more effective at priming for an enhanced salivary IgA response than is injection of a particulate DNP antigen [7], We hypothesized, as had others [28,29], that the injected soluble antigen is more likely to reach remote secretory lymphoid tissue (i.e. salivary gland, Peyer's patches) than is the parti culate antigen which might be filtered from the circu lation more rapidly by secondary lymphoid tissue.…”

Section: Discussionmentioning

confidence: 90%

Oral Induction of the Secretory Antibody Response by Soluble and Particulate Antigens

Cox¹,

Taubman²

1984

Int Arch Allergy Immunol

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The ability of gastric intubation of a soluble or a particulate form of dinitrophenylated bovine γ-globulin (DNP-BGG) to induce salivary IgA antibody was examined. Gastric intubation of the particulate form of the antigen tended to induce a greater response than did equivalent doses of the soluble form. However, systemic immunization with the soluble form of the antigen prior to gastric intubation of antigen increased the salivary IgA response. Prior systemic injection of the particulate form did not increase the salivary IgA response. Immunoreactivity of the particulate moiety of the particulate antigen did not seem to be a factor in the observed differences, since three different synthetic particulate antigens with identical hapten-protein moieties produced the same results (i.e. prior injection with the synthetic particulate antigens did not increase the salivary IgA response).

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Section: Discussionmentioning

confidence: 90%

Oral Induction of the Secretory Antibody Response by Soluble and Particulate Antigens

Cox¹,

Taubman²

1984

Int Arch Allergy Immunol

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“…The most promising results have been obtained with live attenuated viral vaccines, particularly influenza virus vaccine (2,7,8,12,26). Recently, the first intranasal vaccine (FluMist; MedImmune, Inc.) was licensed in the United States (1).…”

Section: Discussionmentioning

confidence: 99%

Intranasal Delivery of Group B Meningococcal Native Outer Membrane Vesicle Vaccine Induces Local Mucosal and Serum Bactericidal Antibody Responses in Rabbits

et al. 2005

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We have previously shown that intranasal immunization of mice with meningococcal native outer membrane vesicles (NOMV) induces both a good local mucosal antibody response and a good systemic bactericidal antibody response. However, in the intranasal mouse model, some of the NOMV entered the lung and caused an acute granulocytic response. We therefore developed an alternate animal model using the rabbit. This model reduces the probability of lung involvement and more closely mimics intranasal immunization of humans. Rabbits immunized intranasally with doses of 100 g of NOMV in 0.5 ml of saline developed serum bactericidal antibody levels comparable to those of rabbits immunized intramuscularly with 25-g doses, particularly when the primary intranasal immunization was given daily for 3 days. Intranasal immunization also induced a local mucosal response as evidenced by immunoglobulin A antibody in saliva, nasal washes, and lung lavage fluids. NOMV from a capsule-deficient mutant induced higher serum bactericidal antibody responses than NOMV from the encapsulated parent. Meningococcal NOMV could be administered intranasally at 400 g with no pyrogenic activity, but as little as 0.03 g/kg of body weight administered intravenously or 25 g administered intramuscularly induced a pyrogenic response. These data indicate that the rabbit is a useful model for preclinical testing of intranasal meningococcal NOMV vaccines, and this immunization regimen produces a safe and substantial systemic and local mucosal antibody response.Efforts to produce an efficacious vaccine against serogroup B Neisseria meningitidis have met with only moderate success. Efficacy studies with outer membrane protein-based vaccines have demonstrated efficacy in the range of 50 to 80% (3,4,10,23). Those vaccines which have undergone recent phase 3 testing might be improved by two potential modifications. First, induction of a local mucosal response to supplement the systemic response may lead to more effective immunization against this organism. Intranasal (i.n.) immunization would be a direct approach to stimulating a mucosal response, since the human nasopharyngeal region is the natural habitat for meningococci, and it is believed that nasopharyngeal carriage leads to natural immunization (14). Secondly, a more effective serum bactericidal antibody response might be stimulated if the proteins were in a more native conformation, without any detergent treatment or extraction of lipooligosaccharide (LOS).In a large efficacy trial conducted in Iquique, Chile, strong anti-outer membrane protein (anti-OMP) antibody responses in young children, as measured by enzyme-linked immunosorbent assay (ELISA), did not correlate with protection or with levels of serum bactericidal activity (4). The vaccine consisted of noncovalent complexes of purified outer membrane proteins (less than 1% LOS) and group C capsular polysaccharide. The relatively low bactericidal antibody response obtained from the volunteers was probably due in part to altered protein conformation and...

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“…The role of secretory antibodies in respiratory disease has received much attention lately (27). However, these studies have primarily stressed viral vaccines (28,29). On the other hand, studies on local cellular immunity have been performed primarily with intrac'Ilular parasites such as Mycobacterium tuberculosis (30,31) and Listeria mnonocytogenes (20), but local immunity against potential bacterial pathogens, whether humoral or cellular, has not received equal attention.…”

Section: Discussionmentioning

confidence: 99%

Immune Enhancement of Pulmonary Bactericidal Activity in Murine Virus Pneumonia

Jakab

Green

1973

J. Clin. Invest.

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Bacterial multiplication in the lung associated with murine Sendai virus pneumonia is caused by virus-induced defects in pulmonary bactericidal mechanisms. The nature of this effect has been studied in animals immunized against the challenge bacteria. Mice were immunized against Proteus mirabilis by intraperitoneal inoculation and by aerosol inhalation. After the development of immunity, mice were infected aerogenically with 10O TCIDso of Sendai virus. 7 days later, during the height of the bronchial inflammation and pulmonary consolidation, the mice were challenged with an aerosol of viable i'S-labeled Proteus mirabilis or 8P-labeled Staphylococcus aureus.Nonimmunized virus-infected animals showed marked impairment of pulmonary bactericidal activity with subsequent multiplication of the bacterial strain in the case of Proteus mirabilis. Immunized nonvirus-infected animals showed enhancement of pulmonary bactericidal activity for the homologous and heterologous strains in comparison with nonimmunized animals. Virus-infected animals immunized by aerosol showed enhanced bactericidal activity against the homologous but not the heterologous bacterial strain. Neither virus infection nor immunization had a significant effect on the transport of particles in the lung. The data demonstrated that the bacterial multiplication associated with the virus pneumonia was prevented by preceding immunization against the homologous challenge organism. The data suggest a mechanism for controlling bacterial multiplication associated with virus pneumonias.

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Influenza Antibody Response Following Aerosal Administration of Inactivated Viruis1

Cited by 91 publications

References 0 publications

Oral Induction of the Secretory Antibody Response by Soluble and Particulate Antigens

Oral Induction of the Secretory Antibody Response by Soluble and Particulate Antigens

Intranasal Delivery of Group B Meningococcal Native Outer Membrane Vesicle Vaccine Induces Local Mucosal and Serum Bactericidal Antibody Responses in Rabbits

Immune Enhancement of Pulmonary Bactericidal Activity in Murine Virus Pneumonia

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