Influenza-attributable years of life lost in older adults in a subtropical city in China, 2012–2017: A modeling study based on a competing risks approach

Hao, Yajing; Huang, Li; Liu, Xuxiang; Chen, Yinzi; Li, Jing; Wang, Xiling

doi:10.1016/j.ijid.2020.06.041

Cited by 3 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on our model, in older adults, influenza-associated excess mortality rates for CVD, IHD and stroke increased with age. Consistent with reports from the USA 18 and Hefei, 23 a subtropical city in China, the highest excess mortality rate was in the ≥85 years group. A study from Singapore found that the burden of influenza on CVD increased with age and was significantly associated with excess hospitalisations for CVD, mainly in people≥80 years old.…”

Section: Discussionsupporting

confidence: 86%

Age-dependent and sex-dependent differences in mortality from influenza-associated cardiovascular diseases among older adults in Shanghai, China: a population-based study

et al. 2022

Self Cite

View full text Add to dashboard Cite

ObjectivesInfluenza epidemics lead to substantial morbidity and mortality among older adults. This study aimed to analyse and assess the age-specific and sex-specific differences in mortality rates for cardiovascular disease (CVD) associated with influenza in older adults.DesignWe obtained weekly data on mortality from CVD in adults≥60 years, categorised into five age groups. We used a quasi-Poisson model and adjusted for long-term and seasonal trends and absolute humidity as confounding factors. The male-to-female ratio (M/F ratio) was an indicator for assessing sex differences.SettingShanghai, China.ParticipantWe analysed 440 107 CVD deaths in adults aged ≥60 years, including 44 913 cases positive for influenza and 1 927 487 outpatient visits for influenza-like illness from 2010 to 2019.Main outcome measuresAge-specific and sex-specific excess CVD mortality rates in older adults for various combinations of CVDs and influenza viruses.ResultsVariations were observed in the excess mortality from CVD, ischaemic heart disease (IHD) and stroke depending on the influenza types/subtypes in different age and sex categories. The ≥85 years group had the highest excess mortality rates per 100 000 persons for CVD, IHD and stroke, while influenza A (H3N2) virus accounted for the highest mortality from CVD, IHD and stroke in people aged ≥65 years. Older men had a significantly lower influenza-associated IHD mortality rate than women, with an M/F ratio of 0.77 (p<0.05).ConclusionsExcess mortality rates for CVDs associated with influenza increased with age in older adults. The risk for influenza-associated IHD mortality was significantly higher in older women than men. Our findings will help implement targeted health strategies, including the promotion of influenza vaccination and early therapeutic intervention for the older population with CVD, to curb the influenza burden effectively.

show abstract

Section: Discussionsupporting

confidence: 86%

Age-dependent and sex-dependent differences in mortality from influenza-associated cardiovascular diseases among older adults in Shanghai, China: a population-based study

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent example of using ( 10 ) is Hao et al. ( 2020 ) who considered influenza‐attributable life years lost before the age of 90.…”

Section: Outcomes Their Analysis and Interpretationmentioning

confidence: 99%

“…This is also related to the ventilator free days discussed in Section 2. A recent example of using ( 10) is Hao et al (2020) who considered influenza-attributable life years lost before the age of 90. Alternatively, one may consider the median time to improvement,…”

Section: "Average" Improvement or Recovery Timesmentioning

confidence: 99%

Design aspects of COVID‐19 treatment trials: Improving probability and time of favorable events

Beyersmann

Friede

Schmoor³

2021

Biometrical J

View full text Add to dashboard Cite

show abstract

“…This is also related to the ventilator free days discussed in Section 2. A recent example of using ( 8) is Hao et al (2020) who considered influenza-attributable life years lost before the age of 90. Alternatively, one may consider the median time to improvement,…”

Section: Competing Events: Time To and Type Of First Eventmentioning

confidence: 99%

Design aspects of COVID-19 treatment trials: Improving probability and time of favourable events

Beyersmann,

Friede,

Schmoor

2020

Preprint

View full text Add to dashboard Cite

As a reaction to the pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a multitude of clinical trials for the treatment of SARS-CoV-2 or the resulting corona disease (COVID-19) are globally at various stages from planning to completion. Although some attempts were made to standardize study designs, this was hindered by the ferocity of the pandemic and the need to set up trials quickly. We take the view that a successful treatment of COVID-19 patients (i) increases the probability of a recovery or improvement within a certain time interval, say 28 days; (ii) aims to expedite favourable events within this time frame; and (iii) does not increase mortality over this time period. On this background we discuss the choice of endpoint and its analysis. Furthermore, we consider consequences of this choice for other design aspects including sample size and power and provide some guidance on the application of adaptive designs in this particular context.

show abstract

Influenza-attributable years of life lost in older adults in a subtropical city in China, 2012–2017: A modeling study based on a competing risks approach

Cited by 3 publications

References 13 publications

Age-dependent and sex-dependent differences in mortality from influenza-associated cardiovascular diseases among older adults in Shanghai, China: a population-based study

Age-dependent and sex-dependent differences in mortality from influenza-associated cardiovascular diseases among older adults in Shanghai, China: a population-based study

Design aspects of COVID‐19 treatment trials: Improving probability and time of favorable events

Design aspects of COVID-19 treatment trials: Improving probability and time of favourable events

Contact Info

Product

Resources

About