Influenza colloidal gold method and blood routine tests combination for rapid diagnosis of influenza: a decision tree-based analysis

Li, Xiaoguang; Chen, Jing; Lin, Fei; Wang, Wei; Xu, Jibin; Li, Nan

doi:10.1038/s41533-021-00251-x

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…The basic information of the patients in the study collected by the doctors using a standardized questionnaire included age, sex, underlying diseases, status of smoking, the onset and clinical course of the infection (including the highest temperature, clinical manifestations, and laboratory tests), use of antiviral drugs (type of drugs and used days), the laboratory test results of IFV (A and B), the clinical manifestations at the 7th day after symptom onset, and clinical outcome (fever days, cough days, number of hospital visits and hospitalization). The colloidal gold method was applied immunochromatography and a double antibody sandwich to detect IFV-A/IFV-B antigens by IFV-A/IFV-B viral antigen detection kit (Guangzhou Wongfo Biotech Co., Ltd., Guangzhou, China) with the sensitivity and specificity of 73.8% and 66.3%, respectively ( Li et al, 2021 ). The number of hospitalizations included the times in the Peking University Third Hospital and in other hospitals.…”

Section: Methodsmentioning

confidence: 99%

Oseltamivir Treatment for Influenza During the Flu Season of 2018–2019: A Longitudinal Study

Chen

Wang

et al. 2022

Front. Microbiol.

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BackgroundOseltamivir resistance in influenza virus (IFV) has been of widespread concern. An increase in the frequency of viruses with reduced inhibition was observed. Whether oseltamivir is effective is uncertain. We conducted this study to understand the real-world situation in northern China and the clinical efficacy for patients with IFV infection after the use of oseltamivir.MethodsThe longitudinal study was performed on influenza-like illness (ILI) cases in a tertiary general hospital in Beijing, China during the flu season of 2018–2019. All ILI cases (≥18 years) were recruited into the study. We analyzed the effect of the oseltamivir therapy on the number of clinic visits, hospitalization frequency, and the duration of fever and cough.ResultsA total of 689 ILI patients were recruited in this study with 355 in the oseltamivir therapy group and 334 in the supportive therapy group. Among the ILI patients, 388 patients were detected for IFV infection (364 IFV-A and 24 IFV-B) and divided into two groups with or without the oseltamivir therapy (302 vs. 86). There were no significant differences in the basic characteristics between the oseltamivir and supportive therapy groups in the ILI patients or in the IFV positive patients (all p < 0.05). After adjusting for the potential confounders, oseltamivir therapy reduced the times of clinic visits in the ILI and IFV positive patients (p = 0.043 and p = 0.011). No effectiveness with oseltamivir therapy was observed in the outcomes of hospitalization frequency, and the duration of fever and cough.ConclusionOseltamivir use may reduce the times of clinic visits. However, we did not observe the differences in the duration of fever, cough, and the frequency of hospitalization between oseltamivir therapy and supportive therapy.

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Section: Methodsmentioning

confidence: 99%

Oseltamivir Treatment for Influenza During the Flu Season of 2018–2019: A Longitudinal Study

Chen

Wang

et al. 2022

Front. Microbiol.

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A rapid, sensitive, and high-throughput pathogen detection method and application of identifying pathogens based on multiplex PCR technology combined with capillary electrophoresis

Pan,

Wang,

Zhang

et al. 2025

Diagnostic Microbiology and Infectious Disease

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Evaluation and control strategy analysis of influenza cases in Jiujiang City, Jiangxi Province, China from 2018 to 2022

Zeng,

Xiong

2024

Geospat Health

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According to World Trade Organization (WTO) statistics, the incidence of seasonal influenza in China has been on the rise since 2018. The aim of this study was to identify and investigate the influence of factors related to the incidence of four common types of influenza viruses. Data of patients with common cold and associated virus infections are described, and a logistic regression model based on gender, age and season was established. The relationship between virus type and the above three factors was analyzed in depth and significant (p<0.05) associations noted. We noted a fluctuation trend, with the infection rate of influenza virus showing an upward trend from 2018 to 2019 and from 2021 to 2022 and a downward trend from 2019 to 2021. The total number of cases in adolescents aged 18-30 years was higher than that in the elderly. The impact of different types of influenza virus on the population ranked from large to small, with special roles played by Influenza B/Victoria, H3N2, Influenza A/H1N1 pdm and Influenza B/Yamagata.

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Influenza colloidal gold method and blood routine tests combination for rapid diagnosis of influenza: a decision tree-based analysis

Cited by 3 publications

References 20 publications

Oseltamivir Treatment for Influenza During the Flu Season of 2018–2019: A Longitudinal Study

Oseltamivir Treatment for Influenza During the Flu Season of 2018–2019: A Longitudinal Study

A rapid, sensitive, and high-throughput pathogen detection method and application of identifying pathogens based on multiplex PCR technology combined with capillary electrophoresis

Evaluation and control strategy analysis of influenza cases in Jiujiang City, Jiangxi Province, China from 2018 to 2022

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