Influenza D Virus in Animal Species in Guangdong Province, Southern China

Zhai, Shao‐Lun; Zhang, He; Chen, Shengnan; Zhou, Xia; Lin, Tao; Liu, Runxia; Lv, Dian-Hong; Wen, Xiaohui; Wei, Wen-Kang; Wang, Dan Dan; Li, Feng

doi:10.3201/eid2308.170059

Cited by 96 publications

(114 citation statements)

References 15 publications

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“…Our results demonstrate that IDV is circulating in cattle herds in Northern Ireland. Its detection in animals with confirmed respiratory disease at a prevalence of 8.7% is in broad agreement with similar studies performed in the United States, Europe and Asia (Collin et al., ; Ducatez et al., ; Ferguson et al., ; Flynn et al., ; Zhai et al., ). For example, Flynn et al.…”

Section: Detection Of Influenza D Virus In Bovine Respiratory Samplessupporting

confidence: 89%

Detection of influenza D virus in bovine respiratory disease samples, UK

Dane

Duffy²,

Guelbenzu-Gonzalo³

et al. 2019

Transbound Emerg Dis

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Influenza D is a newly described virus of cattle, pigs and small ruminants first detected in North America during 2011. Cattle have been shown to be the main viral reservoir and mounting evidence indicates that infection with influenza D may contribute to the development of bovine respiratory disease. The virus has been detected across the United States, Europe and Asia. To date, influenza D has not been reported in the UK. During the winter and spring of 2017/2018, we performed molecular testing of cattle submitted for post-mortem examination where respiratory disease signs were present. We detected influenza D virus in 8.7% of cases, often as the sole viral agent and always in conjunction with bacterial co-infection with one or more agents. Viral RNA was present in both the upper and lower respiratory tract and pathological changes in lung tissues were observed alongside signs of concurrent bacterial infections. Sequencing of one UK isolate revealed that it is similar to viruses from the Republic of Ireland and Italy. K E Y W O R D S influenza D virus, influenza, bovine, respiratory disease This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland.

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Section: Detection Of Influenza D Virus In Bovine Respiratory Samplessupporting

confidence: 89%

Detection of influenza D virus in bovine respiratory disease samples, UK

Dane

Duffy²,

Guelbenzu-Gonzalo³

et al. 2019

Transbound Emerg Dis

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“…The IAV infection was also documented in 44 wild boars in Jilin province of China between April 2015 and February 2016 [101]. The first report of the IDV prevalence in Chinese swine documented 21 IDV positive swine in the Guangdong province in 2016 [44]. The swine IDV sequences shared high similarity (99-100%) with IDV sequences reported earlier from the bovine species in China [102] which indicated the transmission of IDV from bovine to swine in China.…”

Section: Chinamentioning

confidence: 66%

“…While an overwhelming majority of investigations reported IAV in the swine across the world ( Figure 7A), there were only a few reports which documented either active infections or past exposures of the swine to the influenza virus types IBV [37,171,186,277] (Figure 7B), ICV [38,117,186] ( Figure 7C) or IDV [5,[43][44][45][46]217] (Figure 7D). A low prevalence of IBV was observed in swine given that only one study reported the IBV antibodies in swine samples in England during 1991-1992 [186] with no evidence of further spill over to other European countries.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review Analyzing the Prevalence and Circulation of Influenza Viruses in Swine Population Worldwide

Chauhan

Gordon

2020

Pathogens

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The global anxiety and a significant threat to public health due to the current COVID-19 pandemic reiterate the need for active surveillance for the zoonotic virus diseases of pandemic potential. Influenza virus due to its wide host range and zoonotic potential poses such a significant threat to public health. Swine serve as a "mixing vessel" for influenza virus reassortment and evolution which as a result may facilitate the emergence of new strains or subtypes of zoonotic potential. In this context, the currently available scientific data hold a high significance to unravel influenza virus epidemiology and evolution. With this objective, the current systematic review summarizes the original research articles and case reports of all the four types of influenza viruses reported in swine populations worldwide. A total of 281 articles were found eligible through screening of PubMed and Google Scholar databases and hence were included in this systematic review. The highest number of research articles (n = 107) were reported from Asia, followed by Americas (n = 97), Europe (n = 55), Africa (n = 18),

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“…Because of the high seroprevalence, cattle is the proposed natural reservoir of IDV, in which IDV causes mild respiratory disease symptoms (11). In addition to cattle, IDV-specific antibodies have been detected in swine, feral swine, equine, ovine, caprine and camelid species, suggesting a broad host tropism for IDV (3, 4, 9, 12, 13). However, the most striking observation is the detection of IDV-directed antibodies among humans with occupational exposure to livestock (14).…”

Section: Introductionmentioning

confidence: 99%

Determining the replication kinetics and cellular tropism of the ruminant-associated Influenza D virus on primary human airway epithelial cells

Holwerda

Laloli

Stuermer

et al. 2018

Preprint

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One-sentence summary of the conclusion 33 We show that the ruminant-associated Influenza D virus has direct transmission capability to 34 humans. 35 36 Abstract 37 Influenza viruses are notorious pathogens that frequently cross the species barrier with often 38 severe consequences for both animal and human health. In 2011, a novel member of the 39 Orthomyxoviridae family, Influenza D virus (IDV), was identified in the respiratory tract of 40 diseased swine. Epidemiological surveys revealed that IDV is distributed worldwide among 41 livestock and that IDV-directed antibodies are detected in humans with occupational exposure 42 to livestock. To identify the transmission capability of IDV to humans, we determined the 43 viral replication kinetics and cell tropism using an in vitro respiratory epithelium model of 44 humans. The inoculation of IDV revealed efficient replication kinetics and apical progeny 45 virus release at different body temperatures. Intriguingly, the replication characteristics of 46 IDV revealed many similarities to the human-associated Influenza C virus, including the cell 47 tropism preference for ciliated cells. Collectively, these results might indicate why IDV-48 directed antibodies are detected among humans with occupational exposure to livestock. 49 50 51After the initial discovery of Influenza D virus (IDV) in 2011, among swine with Influenza-52 like symptoms, knowledge about this new genus in the family of Orthomyxoviridae is 53 increasing (1, 2). Epidemiological studies have shown that the virus has a worldwide 54 distribution, whereby at least two distinct genetic lineages are cocirculating and reassorting 55 (3-10). Because of the high seroprevalence, cattle is the proposed natural reservoir of IDV, in 56 which IDV causes mild respiratory disease symptoms (11). In addition to cattle, IDV-specific 57 antibodies have been detected in swine, feral swine, equine, ovine, caprine and camelid 58 species, suggesting a broad host tropism for IDV (3, 4, 9, 12, 13). However, the most striking 59 observation is the detection of IDV-directed antibodies among humans with occupational 60 exposure to livestock (14). 61There are several indicators that IDV has a zoonotic potential. For instance, the 62 utilization of the 9-O-acetyl-N-acetylneuraminic acid as a receptor determinant, that allows 63 the hemaglutinin esterase fusion (HEF) glycoprotein of IDV to bind the luminal surface of the 64 human respiratory epithelium (1). Interestingly, the utilization of this receptor is also 65 described for the closely related, human associated Influenza C virus (ICV) (15, 16). 66 Furthermore, the detection of IDV-directed antibodies among humans with occupational 67 exposure to livestock and the molecular detection of IDV in a nasopharyngeal wash of a field 68 worker with close contact to livestock indicates that cross species transmission occurs (14, 69 17). However, thus far, there is no indication of wide spread prevalence among the general 70 population although the virus has been detect...

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Influenza D Virus in Animal Species in Guangdong Province, Southern China

Cited by 96 publications

References 15 publications

Detection of influenza D virus in bovine respiratory disease samples, UK

Detection of influenza D virus in bovine respiratory disease samples, UK

A Systematic Review Analyzing the Prevalence and Circulation of Influenza Viruses in Swine Population Worldwide

Determining the replication kinetics and cellular tropism of the ruminant-associated Influenza D virus on primary human airway epithelial cells

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