“…A stratified, randomized, double-blind, placebo-controlled trial in 2004 in Thailand revealed that the effectiveness of influenza vaccination was not modified by the severity of chronic obstructive pulmonary disease (COPD; mild, moderate, severe) [18••]. The concern among practitioners that influenza vaccine may induce acute exacerbations in those with COPD has contributed to suboptimal rates of vaccine uptake in this group [19,20]. A population-based cohort study of 12,000 elderly individuals with COPD or asthma in 2003 found no increased risk of adverse acute outcomes in the first 2 weeks after influenza vaccination [21].…”