Influenza vaccination induced leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis

Yanai-Berar, N; Ben-Itzhak, Ofer; Gree, J; Nakhoul, Farid

doi:10.5414/cnp58220

Cited by 27 publications

(15 citation statements)

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“…Systemic side-effects of the influenza vaccine are rare, but Yanai-Berar et al [9] have summarized their report on renal dysfunction, and Kielstein et al [20] have reported a patient with an onset of minimal change nephrotic syndrome 4 days after influenza vaccine administration. In our case, since nephrotic syndrome occurred 10 days after vaccine inoculation and the drug-induced lymphocyte stimulation test performed on the influenza vaccine was positive, we considered that the influenza vaccine had some effect on the recurrence of nephrotic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the selectivity index was 0.125. A drug-induced lymphocyte stimulation test for the influenza vaccine was positive, and since there have been reports [9] of kidney diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis occurring after administration of an influenza vaccine, a second renal biopsy was performed. The renal biopsy results showed mild mesangial proliferative nephritis in 13 of 15 glomeruli, and the findings were almost identical to those of the first renal biopsy, including IgA, IgM and C3 depositions observed in the mesangial area by immunofluorescence microscopy.…”

Section: Casementioning

confidence: 99%

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A case of minimal change nephrotic syndrome with immunoglobulin A nephropathy transitioned to focal segmental glomerulosclerosis

et al. 2012

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A 50-year-old woman with a 1-month history of lower extremity edema and a 5 kg weight increase was admitted to our hospital with suspected nephrotic syndrome in October 1999. Urine protein level was 3.5 g per day, 10-15 erythrocytes in urine per high-power field, and serum albumin level 2.5 g/dl. Furthermore, an accumulation of pleural effusion was confirmed by chest X-ray. The results of a renal biopsy indicated slight mesangial proliferation in the glomeruli by light microscopy, and an immunofluorescence study confirmed the deposition of immunoglobulin (Ig) A and C3 in the mesangial area. Diffuse attenuation of foot processes and dense deposits in the mesangial area were observed by electron microscopy. Treatment with 40 mg/day of prednisolone was effective, and proteinuria was negative 1 month later. Because of this course, we diagnosed minimal change nephrotic syndrome complicated by mild-proliferative IgA nephropathy. In November 2000, there was a relapse of nephrotic syndrome, which was believed to be induced by an influenza vaccination, but response to increased steroid treatment was favorable, and proteinuria disappeared on day 13 of steroid increase. A second relapse in May 2001, showed steroid resistance with renal insufficiency, and an increase in the selectivity index to 0.195. Light microscopy revealed focal sclerotic lesions of the glomeruli, and an immunofluorescence study revealed attenuation of mesangial IgA and C3 deposition. These findings led to the diagnosis that minimal change nephrotic syndrome had transitioned to focal segmental glomerulosclerosis, whereby mesangial IgA deposition was reduced by immunosuppressive treatment. Subsequently, her renal function gradually worsened to the point of end-stage renal failure by 27 months after the second relapse of nephrotic syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Casementioning

confidence: 99%

A case of minimal change nephrotic syndrome with immunoglobulin A nephropathy transitioned to focal segmental glomerulosclerosis

et al. 2012

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“…Over the past thirty years various types of vasculitis associated with influenza vaccination have been reported (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The present case of microscopic polyangiitis also occurred after influenza vaccination.…”

Section: Discussionmentioning

confidence: 59%

“…Two mechanisms of damage to the vessel wall can be suggested (2,8), with one being a direct effect of the vaccine itself and the other being through an immunological activation. In the present case a high serum level of sIL-2R was seen.…”

Section: Discussionmentioning

confidence: 99%

Microscopic Polyangiitis after Influenza Vaccination

Uji¹,

Matsushita

Iwata

2005

Intern. Med.

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After influenza vaccination an 83-year-old woman was referred to us because of fever and sore throat with no response to antibiotics. Chest computed tomography showed thickened bronchovascular bundles, multiple nodules with feeding vessels, and consolidation. Laboratory tests showed a high level of serum myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) and soluble interleukin-2 receptor (sIL-2R), as well as abnormal renal function and urinary sediment. Transbronchial lung biopsy revealed organizing pneumonia. We made a diagnosis of microscopic polyangiitis after influenza vaccination. Corticosteroids and cyclophosphamide were effective. Careful attention should be paid to severe adverse effects such as systemic vasculitides after influenza vaccination.

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“…Yanai-Berar N ve arkadaşları influenza aşısın yapıldıktan sonra artralji, myalji, purpura nedenleri ile acil servise başvuran hastanın böbrek biyopsisinde pauci-immun glomerülonefrit ile ilişkili nekrotizan vaskulit tespit edildiğini bildirmiş, influenza aşısının vaskulit ve glomerülonefrite yol açtığını rapor etmişlerdir (9). Bizim vakamızda ise hastanın böyle bir hikayesi yoktu.…”

Section: Discussionunclassified

Cause of Nephrotıc Syndrome at A Case Admitted About Leukocytoclastic Vasculitis: Focal Segmental Glomerulosclerosis

Tamer¹,

Emre²,

Korkmaz³

et al. 2015

ADUTFD

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Influenza vaccination induced leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis

Cited by 27 publications

References 0 publications

A case of minimal change nephrotic syndrome with immunoglobulin A nephropathy transitioned to focal segmental glomerulosclerosis

A case of minimal change nephrotic syndrome with immunoglobulin A nephropathy transitioned to focal segmental glomerulosclerosis

Microscopic Polyangiitis after Influenza Vaccination

Cause of Nephrotıc Syndrome at A Case Admitted About Leukocytoclastic Vasculitis: Focal Segmental Glomerulosclerosis

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