Influenza Vaccinations: Should They Really be Encouraged for IBD Patients Being Treated with Immunosuppressives?

Fields, Susan; Baiocco, Peter J.; Korelitz, Burton I.

doi:10.1002/ibd.20731

Cited by 16 publications

(8 citation statements)

References 8 publications

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“…The most common is lack of awareness (58%), however, fear of side effects (33%) and fear of disease activation (5%) are also factors which need to be addressed [5]. Evidence suggesting that influenza vaccine causes IBD activation is limited to case reports, and in fact there is robust data indicating the opposite -IBD patients do not require additional health services following vaccination [17][18][19][20][21]. In most Western countries, including Israel, low vaccine availability and poor access to healthcare are of only minor relevance [1].…”

Section: Discussionmentioning

confidence: 99%

Uptake of influenza vaccine in ulcerative colitis

Boltin

Gingold‐Belfer

Kimchi

et al. 2014

Vaccine

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Section: Discussionmentioning

confidence: 99%

Uptake of influenza vaccine in ulcerative colitis

Boltin

Gingold‐Belfer

Kimchi

et al. 2014

Vaccine

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“…13,17 Evidence of IBD flares following vaccination is limited to 3 case reports. [18][19][20] Efficacy of influenza vaccine in patients with IBD has been the subject of previous study. Although influenza B elicits a diminished immunogenic response compared with influenza A, seroprotection is generally achieved.…”

Section: Discussionmentioning

confidence: 99%

Utilization of Influenza Immunization in Adults with Crohnʼs Disease—A Longitudinal, Population-Based Study

Boltin

Gingold‐Belfer

Kimchi

et al. 2014

Inflammatory Bowel Diseases

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“…Although case reports of IBD flares after influenza immunization exist, [8][9][10] observational studies demonstrated no association with flare of disease. 24,28 However, these were underpowered to demonstrate rare events, nor did they document less serious events that may have prompted outpatient physician visits.…”

Section: Figurementioning

confidence: 99%

“…5 Nevertheless, surveys of gastroenterologists have demonstrated inadequate knowledge of immunization recommendations and poor rates of administration of vaccines to their patients. 6,7 In addition, observational reports have raised concerns regarding adverse events and IBD flares associated with influenza immunization, [8][9][10] and epidemiologic evidence evaluating the safety of influenza immunization in IBD patients is lacking. 11,12 Ontario, Canada, has among the highest rates of childhood-onset IBD in the world, 13 and all cases are followed longitudinally in the Ontario Crohn' s and Colitis Cohort (OCCC), a populationbased registry of pediatric IBD patients derived from provincial health administrative data.…”

mentioning

confidence: 99%

Safety and Utilization of Influenza Immunization in Children With Inflammatory Bowel Disease

et al. 2013

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OBJECTIVE: Influenza immunization is recommended for children with IBD, however safety concerns may limit uptake. This study assessed whether immunization was associated with adverse events in IBD patients using a population-based database of children with IBD. METHODS: All children <19 years diagnosed with IBD in Ontario, Canada between 1999–2009 were identified using health administrative data, and matched to non-IBD controls. Self-controlled case series (SCCS) analyses determined health services event rates (outpatient visits, hospitalizations and emergency visits) in any 2-week risk period to 180 days post-immunization compared to a no-risk control period. Relative incidence (RI) was calculated for overall and IBD-related events and rates were compared between IBD cases and controls using relative incidence ratios (RIR). RESULTS: A total of 4916 IBD patients were matched to 21 686 controls. IBD patients were more likely to have received immunization than controls (25.3% vs 13.2%, P < .001). No increased event rates existed in IBD cases during risk periods (pooled RI 0.95, 95% CI 0.84–1.07), including hospitalizations and emergency visits. There was a slightly higher event rate in IBD cases versus controls for days 3–14 (RIR 1.60, 95% CI 1.05–2.44, P = .03). IBD-related visit rates were lower in risk periods compared to control period (pooled RI 0.81, 95% CI 0.68–0.96). CONCLUSIONS: There was no increase in health services use in the post-vaccine risk period in IBD patients, and there was evidence for a protective effect of influenza immunization against IBD-related health services use. Influenza immunization is safe in children with IBD and should be encouraged to improve poor coverage rates.

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Influenza Vaccinations: Should They Really be Encouraged for IBD Patients Being Treated with Immunosuppressives?

Cited by 16 publications

References 8 publications

Uptake of influenza vaccine in ulcerative colitis

Uptake of influenza vaccine in ulcerative colitis

Utilization of Influenza Immunization in Adults with Crohnʼs Disease—A Longitudinal, Population-Based Study

Safety and Utilization of Influenza Immunization in Children With Inflammatory Bowel Disease

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