“…Our findings mainly confirm that there is no effect of influenza split vaccination on memory impairment in MOG induced EAE mice and no significant influence on hippocampal-dependent spatial learning. Additionally, although clinical signs of EAE are very subtle, the lesions that have been found in the hippocampal region of the brain could be associated with memory dysfunction observed during the course of MWM testing 114 . Even though the initial studies have demonstrated that influenza infection induces deficits in spatial learning and memory loss in adult mice at day 7 post infection, conflicting data exist regarding the connection between MS and other autoimmune illnesses and vaccination 95,111 .…”