Influenza vaccine coverage, influenza-associated morbidity and all-cause mortality in Catalonia (Spain)

Muñoz, M. Pilar; Soldevila, Núria; Martínez, A.; Carmona, Glòria; Batalla, J.; Acosta, Lesly; Domı́nguez, Àngela

doi:10.1016/j.vaccine.2011.04.067

Cited by 10 publications

(6 citation statements)

References 34 publications

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“…Differences in the magnitude of estimates from the two methods will be not only because they include bronchitis deaths but also because the rate difference-type method used by Fleming and colleagues tends to produce higher estimates of excess than the Serfling-type method we used, due to a lower reference mortality and the mortality rate in the ‘influenza-active periods’ being entirely attributed to influenza 55. There has been much interest in measuring the impact of influenza vaccination campaigns in other settings 14 15 17 56. Excess all-cause mortality declined in the Dutch elderly after the introduction of universal yearly vaccination of those aged 65 years and over, which saw yearly coverage reach 80% 14.…”

Section: Discussionmentioning

confidence: 98%

The impact of targeting all elderly persons in England and Wales for yearly influenza vaccination: excess mortality due to pneumonia or influenza and time trend study

et al. 2013

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ObjectiveTo investigate the impact on mortality due to pneumonia or influenza of the change from risk-based to age group-based targeting of the elderly for yearly influenza vaccination in England and Wales.DesignExcess mortality estimated using time series of deaths registered to pneumonia or influenza, accounting for seasonality, trend and artefacts. Non-excess mortality plotted as proxy for long-term trend in mortality.SettingEngland and Wales.ParticipantsPersons aged 65–74 and 75+ years whose deaths were registered to underlying pneumonia or influenza between 1975/1976 and 2004/2005.Outcome measuresMultiplicative effect on average excess pneumonia and influenza deaths each winter in the 4–6 winters since age group-based targeting of vaccination was introduced (in persons aged 75+ years from 1998/1999; in persons aged 65+ years from 2000/2001), estimated using multivariable regression adjusted for temperature, antigenic drift and vaccine mismatch, and stratified by dominant circulating influenza subtype. Trend in baseline weekly pneumonia and influenza death rates.ResultsThere is a suggestion of lower average excess mortality in the six winters after age group-based targeting began compared to before, but the CI for the 65–74 years age group includes no difference. Trend in baseline pneumonia and influenza mortality shows an apparent downward turning point around 2000 for the 65–74 years age group and from the mid-1990s in the 75+ years age group.ConclusionsThere is weakly supportive evidence that the marked increases in vaccine coverage accompanying the switch from risk-based to age group-based targeting of the elderly for yearly influenza vaccination in England and Wales were associated with lower levels of pneumonia and influenza mortality in older people in the first 6 years after age group-based targeting began. The possible impact of these policy changes is observed as weak evidence for lower average excess mortality as well as a turning point in baseline mortality coincident with the changes.

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Section: Discussionmentioning

confidence: 98%

The impact of targeting all elderly persons in England and Wales for yearly influenza vaccination: excess mortality due to pneumonia or influenza and time trend study

et al. 2013

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“…The efficacy and effectiveness of influenza vaccination for multiple possible outcome measures, including the prevention of medically attended acute respiratory illness, prevention of laboratory-confirmed influenza, prevention of influenza- or pneumonia-associated hospitalizations or deaths, and prevention of seroconversion to circulating influenza virus strains, has been assessed in clinical trials and observational studies in different populations. 1 , 2 , 4 - 6 In a recent meta-analysis, Osterholm et al 2 found that influenza vaccines can provide moderate protection against virologically confirmed influenza, but that such protection is greatly reduced or absent in some seasons. Even so, current influenza vaccines will continue to play a role in reducing the morbidity of influenza until more effective interventions are available.…”

Section: Introductionmentioning

confidence: 99%

Coverage and predictors of vaccination against 2012/13 seasonal influenza in Madrid, Spain

Jiménez‐García

Esteban-Vasallo

Rodríguez-Rieiro

et al. 2013

Human Vaccines & Immunotherapeutics

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We aim to determine 2012–13 seasonal influenza vaccination coverage. Data were analyzed by age group and by coexistence of concomitant chronic conditions. Factors associated with vaccine uptake were identified. We also analyze a possible trend in vaccine uptake in post pandemic seasons.We used computerized immunization registries and clinical records of the entire population of the Autonomous Community of Madrid, Spain (6 284 128 persons) as data source.A total of 871 631 individuals were vaccinated (13.87%). Coverage for people aged ≥ 65 years was 56.57%. Global coverage in people with a chronic condition was 15.7% in children and 18.69% in adults aged 15–59 years.The variables significantly associated with a higher likelihood of being vaccinated in the 2012–13 campaign for the age groups studied were higher age, being Spanish-born, higher number of doses of seasonal vaccine received in previous campaigns, uptake of pandemic vaccination, and having a chronic condition.We conclude that vaccination coverage in persons aged <60 years with chronic conditions is less than acceptable. The very low coverage among children with chronic conditions calls for urgent interventions. Among those aged ≥60 years, uptake is higher but still far from optimal and seems to be descending in post-pandemic campaigns. For those aged ≥65 years the mean percentage of decrease from the 2009/10 to the actual campaign has been 12%.Computerized clinical and immunization registers are useful tools for providing rapid and detailed information about influenza vaccination coverage in the population.

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“…This function was used to identify trend changes over the study period; SC show specific four-week periods when the incidence of whooping cough changed its previous behaviour (increases or decreases) [21]. …”

Section: Methodsmentioning

confidence: 99%

Geographical differences in whooping cough in Catalonia, Spain, from 1990 to 2010

et al. 2014

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BackgroundWhooping cough is a communicable disease whose incidence has increased in recent years in some countries with vaccination. Since 1981, in Catalonia (Spain), cases must be reported to the Public Health Department. In 1997, surveillance changed from aggregated counts to individual report and the surveillance system was improved after 2002. Catalan public health is universal with equal coverage geographically. The aim of this study was to determine whether there are differences in whooping cough incidence in rural and urban counties.MethodsCases in 1990–2010 were classified as rural or urban. Incidences and risk ratios (RR) between urban and rural counties and 95% CI were calculated. Associations between rural and urban counties and structural changes during the study period were analysed.ResultsTwelve years of the whole study period showed differences in incidence between rural and urban counties. The incidence was higher in urban counties in seven years and rural counties in five years. There was a positive association of whooping cough incidence in rural and urban counties in four-week periods. Structural changes were detected in the following four-week periods: 4th in 1993, 7th in 1996 and 3rd 2005 in rural counties and 5th 1993, 9th in 1996 and 8th in 2007 in urban counties.ConclusionsDifferences in whooping cough between rural and urban counties were found. In most years, the incidence was higher in urban than in rural counties. Rural and urban counties show similar cyclic behaviour when four-week periods were considered.

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Influenza vaccine coverage, influenza-associated morbidity and all-cause mortality in Catalonia (Spain)

Cited by 10 publications

References 34 publications

The impact of targeting all elderly persons in England and Wales for yearly influenza vaccination: excess mortality due to pneumonia or influenza and time trend study

The impact of targeting all elderly persons in England and Wales for yearly influenza vaccination: excess mortality due to pneumonia or influenza and time trend study

Coverage and predictors of vaccination against 2012/13 seasonal influenza in Madrid, Spain

Geographical differences in whooping cough in Catalonia, Spain, from 1990 to 2010

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