Influenza vaccine: enhancement of immune response by application of carboxy-vinylpolymer

Oka, Takahiro; Honda, T; Ohkuma, Kunio; Sakoh, Mitsuo; Nonaka, Saneo

doi:10.1016/0264-410x(90)90011-a

Cited by 14 publications

(2 citation statements)

References 8 publications

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“…The use of pseudo‐affinity based on cellulose sulfate for influenza virus purification has been described in the literature (Junter & Lebrun, 2020; Oka et al, 1988). The use of ligands that resemble Heparin, a naturally occurring glycosaminoglycan, for which several hemagglutinins are known to have affinity have been explored (Skidmore et al, 2015).…”

Section: Next‐generation Downstream Processing For Influenzamentioning

confidence: 99%

Downstream processing for influenza vaccines and candidates: An update

Carvalho

Peixoto

Carrondo

et al. 2021

Biotech & Bioengineering

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Seasonal and pandemic influenza outbreaks present severe health and economic burdens. To overcome limitations on influenza vaccines' availability and effectiveness, researchers chase universal vaccines providing broad, long-lasting protection against multiple influenza subtypes, and including pandemic ones.Novel influenza vaccine designs are under development, in clinical trials, or reaching the market, namely inactivated, or live-attenuated virus, virus-like particles, or recombinant antigens, searching for improved effectiveness; all these bring downstream processing (DSP) new challenges. Having to deal with new influenza strains, including pandemics, requires shorter development time, driving the development of faster bioprocesses. To cope with better upstream processes, new regulatory demands for quality and safety, and cost reduction requirements, new unit operations and integrated processes are increasing DSP efficiency for novel vaccine formats.This review covers recent advances in DSP strategies of different influenza vaccine formats. Focus is given to the improvements on relevant state-of-the-art unit operations, from harvest and clarification to purification steps, ending with sterile filtration and formulation. The development of more efficient unit operations to cope with biophysical properties of the new candidates is discussed: emphasis is given to the design of new stationary phases, 3D printing approaches, and continuous processing tools, such as continuous chromatography. The impact of the production platforms and vaccine designs on the downstream operations for the different influenza vaccine formats approved for this season are highlighted.

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Section: Next‐generation Downstream Processing For Influenzamentioning

confidence: 99%

Downstream processing for influenza vaccines and candidates: An update

Carvalho

Peixoto

Carrondo

et al. 2021

Biotech & Bioengineering

View full text Add to dashboard Cite

show abstract

“…Muir et al indicated that PAA has adjuvant effects on humoral and cell-mediated immunity. [9][10][11] Different researchers have shown the adjuvant effect of PAA in several types of infection. A recent study has reported the development of the immunogenic lipophosphoglycan molecule isolated from Leishmania parasites conjugated with PAA.…”

Section: Introductionmentioning

confidence: 99%