Influenza vaccines for preventing coronary heart disease

Keller, Tymen; Weeda, Víola B.; Dongen, Carlo J van; Levi, Marcel

doi:10.1002/14651858.cd005050.pub2

Cited by 33 publications

(31 citation statements)

References 21 publications

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“…[259] A 2008 Cochrane review of vaccine effects on patients with coronary heart disease included 2 trials and concluded that the small numbers of outcomes of interest, such as cardiovascular death and myocardial infarction, resulted in imprecise estimates and insufficient data to evaluate this association. [10] Compared to healthy populations, vaccine performance may be decreased in populations with underlying respiratory and/or cardiovascular diseases, and meta-analyses indicate that there is insufficient evidence to conclude that vaccines are adequately effective in these groups. A 2003-04 case control study of high risk (with reported underlying medical conditions) and non-high risk 50-64 year olds found a decreased vaccine efficacy against laboratory confirmed influenza among high risk compared to non-high risk individuals (48% vs. 60%).…”

Section: Disease Burdenmentioning

confidence: 99%

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Rondy¹,

Launay

Puig-Barberà

et al. 2015

Eurosurveillance

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Section: Disease Burdenmentioning

confidence: 99%

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Rondy¹,

Launay

Puig-Barberà

et al. 2015

Eurosurveillance

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show abstract

“…9 Although several observational studies, as well as two randomized controlled trials, 10,11 suggest a positive effect of influenza vaccine in preventing acute myocardial infarction, they provide insufficient and conflicting evidence. 12 The aim of this study was to investigate a possible association between influenza or pneumococcal vaccination and acute myocardial infarction. registered with a general practitioner, and all health care attendances are recorded in the database.…”

mentioning

confidence: 99%

Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study

Siriwardena¹,

Gwini²,

Coupland³

2010

Canadian Medical Association Journal

100

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“…7 In addition, randomized controlled trials provide some evidence that influenza vaccination may reduce the risk of myocardial infarction and cardiovascular death. 8 The pathophysiology of this effect is not understood. Both clinically defined influenzalike illness and community-acquired pneumonia are associated with significant rates of cardiac complications, 9 and the association with influenza may be specific to infection, or some types of infection, rather than influenza itself.…”

Section: Discussionmentioning

confidence: 99%

“…A Cochrane review concluded that there are insufficient data to draw firm conclusions on the effect of vaccination in preventing cardiac complications. 8 …”

Section: Preventionmentioning

confidence: 99%

Cardiac complications of influenza infection in 3 adults

Jeyanathan

Overgaard

McGeer

2013

CMAJ

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A 57-year-old man was admitted to the coronary intensive care unit with severe pulmonary edema after a 5-day history of influenza-like illness. His medical history included previous tobacco use and a family history of early myocardial infarction. He had received the seasonal influenza vaccine in the fall before presentation.On examination, he was in marked respiratory distress. His temperature was 38.4 ºC, respiratory rate was 33 breaths/min, and oxygen saturation was 86% on 100% nonrebreather mask. His blood pressure and heart rate were within normal limits. Respiratory examination revealed diffuse bilateral crackles. An electrocardiogram (ECG) taken on admission showed left bundle branch block, and his cardiac troponin I level was 0.77 (normal < 0.07) µg/L. There was no previous ECG available for comparison. Echocardiography showed left ventricular dilatation, moderate hypokinesis with regional variability and an ejection fraction of about 30% (Figure 1). A radiograph of his chest showed left ventricular dilatation with air-space opacification consistent with moderate pulmonary edema. The differential diagnosis was viral myocarditis with heart failure, acute coronary syndrome with heart failure or community-acquired pneumonia with acute respiratory distress syndrome.Despite supplemental oxygen and diuresis therapy, the patient's hypoxemia worsened and intubation was required; high-frequency oscillatory support and norepinephrine for blood pressure support were also required. He was given empirical treatment with oseltamivir, ceftriaxone and azithromycin, and dual antiplatelet therapy (acetylsalicylic acid and clopidogrel).On repeat testing, the patient's cardiac troponin I level was 0.48 µg/L, and his creatine kinase level was 2561 (normal < 240) U/L. Influenza A (pH1N1) was detected in bronchoalveolar lavage samples by polymerase chain reaction. All other culture samples were negative. Repeat echocardiography showed no improvement in left ventricular function. His course in hospital was complicated by dysphagia, and magnetic resonance imaging showed a small lacunar infarct. He was discharged to a stroke rehabilitation centre 40 days after admission. A persantine cardiolite study performed on an outpatient basis did not show any cardiac ischemia but suggested possible prior myocardial infarction. Diagnostic coronary angiography showed mild to moderate plaque in several small branch vessels but no hemodynamically important atherosclerotic coronary artery disease.In the second case, a 67-year-old woman presented to the emergency department with a 1-week history of cough and pleuritic chest pain. Her medical history included hypertension, dyslipidemia, diabetes, obesity and smoking, and she had a family history of coronary artery disease. She had not previously received influenza vaccine. In the emergency department, she had cardiac arrest with pulseless electrical activity that required intubation, mechanical ventilation and 10 minutes of cardiopulmonary resuscitation. An ECG obtained after the arrest showed 0.5...

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Influenza vaccines for preventing coronary heart disease

Cited by 33 publications

References 21 publications

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study

Cardiac complications of influenza infection in 3 adults

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