Influenza Vaccines: Unmet Needs and Recent Developments

Noh, Ji Yun

doi:10.3947/ic.2013.45.4.375

Cited by 20 publications

(15 citation statements)

References 91 publications

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“…Four influenza pandemics, namely H1N1 Spanish influenza in 1918, H2N2 Asian influenza in 1957, H3N2 Hong Kong influenza in 1968, and H1N1 swine influenza in 2009, occurred in the past (Noh and Kim, 2013). Each influenza pandemic virus can arise directly from an avian host (1918) through both an avian virus and a circulating human strain (1957 and 1968) or from influenza virus in pigs (2009), which is transmitted among the human population and causes substantial morbidity and mortality (Cox and Subbarao, 1999;Kerkhove et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Sun

Cong

et al. 2019

International Journal of Infectious Diseases

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To investigate epidemiological features and trends of influenza incidence with 1,173,640 cases in mainland China from 2005 to 2015. Methods: Incidence and mortality data for influenza from 2005 to 2015 were provided by the data-center of China public health science and covered a population of about 1.3 billion people from 31 provinces and regions in mainland China. Joinpoint regression and exploratory spatial data analyses were used to examine the incidence trends from 2005 to 2015. Results: The first upsurge in influenza cases occurred in 2009, and the highest incidence of influenza occurred in 2014 (15.9045 cases/100,000 people). The average incidence per year from 2009 to 2015 was threefold higher than that from 2005 to 2008 (10.5308 vs 3.4589 cases/100,000 people; incidence rate ratio = 3.0446). The joinpoint regression results showed that there was an increasing influenza incidence trend from 2005 to 2015 (annual change in percentage = 13.6%, 95%CI 2.2-26.3, p = 0.0236). The seasonal pattern analysis showed that influenza typically occurred in winter and spring during each monitoring year, peaking from November to March the next year. Conclusions: This study will help governments to make valuable decisions in allocating scarce resources and providing strategies to limit the spread of influenza.

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Section: Discussionmentioning

confidence: 99%

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Sun

Cong

et al. 2019

International Journal of Infectious Diseases

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“…[129][130][131] In addition, there are unmet needs associated with current influenza vaccines. 132 This motivates the development of alternate delivery systems such as MNs that may offer enhanced vaccine uptake and acceptance. 133 If a MN-based vaccine exhibited enhanced stability and lower vaccine doses could be used, 29,30 then this could be attractive to vaccine manufacturers.…”

Section: Influenza: a Popular Vaccine Targetmentioning

confidence: 99%

The success of microneedle-mediated vaccine delivery into skin

Marshall

Sahm

Moore

2016

Human Vaccines & Immunotherapeutics

121

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Microneedles (MNs) are designed to specifically target the outermost, skin barrier layer, the stratum corneum, creating transient pathways for minimally invasive transcutaneous delivery. It is reported that MNs can facilitate delivery without stimulating the pain receptors or damaging blood vessels that lie beneath, thus being perceived as painless and associated with reduced bleeding. This immunocompetence of the skin, coupled with its ease of access, makes this organ an attractive vaccination site. The purpose of this review was to collate primary scientific literature pertaining to MN-mediated in vivo vaccination programmes. A total of 62 original research articles are presented, compiling vaccination strategies in 6 different models (mouse, rat, guinea pig, rabbit, pig, macaque and human). Vaccines tested span a wide range of viral, bacterial and protozoan pathogens and includes 7 of the 13 vaccine-preventable diseases, as defined by the WHO. This review highlights the paucity of available clinical trial data. MN-delivered vaccines have demonstrated safety and immunogenicity in pre-clinical models and boast desirable attributes such as painless administration, thermostability, dose-sparing capacity and the potential for self-administration. These advantages should contribute to enhanced global vaccine access.

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“…Patient compliance was determined as previously described (Noh and Kim, 2013). Briefly, compliance of each group was calculated as the number of patients receiving three months treatment / (total number of patients -number of patients without full data) x 100%.…”

Section: Compliancementioning

confidence: 99%

Combined effect of traditional Chinese and Western medicine on inflammatory factors in patients with diabetes-induced xerophthalmia

Wu¹,

Dai²,

Xu³

et al. 2016

Genet. Mol. Res.

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Diabetes-induced xerophthalmia is a general metabolic disorder with high incidence and increased treatment difficulty. Our study aimed to explore the combined effect of traditional Chinese and Western medicines on diabetes-associated xerophthalmia. We recruited 60 diabetic xerophthalmia patients, and randomly assigned them to either the control (Western medicine treatment) or the experimental (combined treatment of traditional Chinese medicine and Western medicine) groups. Pre-treatment and post-treatment analyses were performed to assess the combined therapeutic effect of traditional Chinese and Western medicine on xerophthalmia-associated indicators. We found that the experimental group expressed reduced levels of IL-1, IL-8, and TNF-α (P < 0.05) as compared to the control group. Furthermore, the experimental group showed higher treatment efficacy as compared to the control group (85.00 vs 51.67% Z = 22.244, P < 0.05). In addition, break-up time (t = 20.582, P < 0.05) and tear section (t = 23.082, P < 0.05) was increased in the experimental group as compared to the controls. Lastly, it was found that the combined treatment of traditional Chinese and Western medicine effectively reduced corneal injuries, as indicated by reduced fluorescein staining. This study suggested that a combination treatment consisting of both traditional Chinese and Western medicines may be effective against xerophthalmia in diabetes, and that inflammatory factors are potential biomarkers to examine the treatment efficacy.

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Influenza Vaccines: Unmet Needs and Recent Developments

Cited by 20 publications

References 91 publications

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

The success of microneedle-mediated vaccine delivery into skin

Combined effect of traditional Chinese and Western medicine on inflammatory factors in patients with diabetes-induced xerophthalmia

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