2016
DOI: 10.1016/j.virol.2016.08.025
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Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung

Abstract: The immunological mechanisms of secondary bacterial infection followed by influenza virus infection were examined. When mice were intranasally infected with influenza virus A and then infected with P. aeruginosa at 4 days after viral infection, bacterial clearance in the lung significantly decreased compared to that of non-viral infected mice. Neutrophils from viral infected mice showed impaired digestion and/or killing of phagocytized bacteria due to reduced myeloperoxidase (MPO) activity. G-CSF production in… Show more

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Cited by 39 publications
(40 citation statements)
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“…41 This is consistent with experimental evidence that these cells become dysfunctional throughout influenza. [133][134][135][136][137] The contribution from neutrophils may be higher during low-dose infection, 41…”
Section: Defining the Contribution Of Other Mechanismsmentioning
confidence: 99%
“…41 This is consistent with experimental evidence that these cells become dysfunctional throughout influenza. [133][134][135][136][137] The contribution from neutrophils may be higher during low-dose infection, 41…”
Section: Defining the Contribution Of Other Mechanismsmentioning
confidence: 99%
“…While type I interferons play an important role in anti-viral responses, the cell factors involved in interferon signalling could also disrupt anti-bacterial responses. 12 Although researchers have found some evidence for an explanation as to why the immune system might be disrupted by viral infection, such as suppression of phagocytic activity and dysfunction of macrophages and neutrophils through reduced granulocyte-colony stimulating factor production, 9,12,13 the increased risk of secondary bacterial infection in the lung following IAV infection needs further research into the changes in the immune response, pathogenesis and drug therapy. In these areas of research, bioluminescence imaging technology might offer unique advantages in terms of providing rapid visual monitoring of bacterial colonization and clearance dynamics.…”
Section: Discussionmentioning
confidence: 99%
“…The IAV/PR8 source and culture conditions were as described in a previous study. 9 Under anaesthesia, mice were intranasally infected with 50 μl of 0.01 M phosphate-buffered saline (PBS; pH 7.4) containing 50 EID 50 of IAV/PR8 or 0.01 M PBS (pH 7.4) alone as a control.…”
Section: Methodsmentioning
confidence: 99%
“…Altogether, out work highlights the capacity of IAV to promote further PAO1-mediated lung damage, not through its interference with host resistance to the bacterium (16,19), but through down-regulating tissue resilience to lung inflammation instead. Our study therefore suggests that restoring tissue resilience in clinical settings where IAV/P.a co-exist could be a fruitful strategy.…”
Section: Introductionmentioning
confidence: 95%
“…These include, not exhaustively however, IAV-mediated desensitization of TLR signaling (13), type I interferonmediated impairment of neutrophil chemokines or function (14)(15)(16)(17), down-regulation of antimicrobial production (18)(19)(20), attenuation of IL1β production or IL1β-mediated alveolar macrophage activity (21,22), exaggerated inflammatory responses (23,24), or loss of lung repair potential (25,26).…”
Section: Introductionmentioning
confidence: 99%