Integrating Information and Communication Technologies (ICTs) in tertiary education is pivotal in enhancing accessibility, quality, and inclusivity in learning, particularly in developing nations such as Nigeria. Despite the transformative potential, challenges like the digital divide, limited infrastructure, and resistance to change persist. This conceptual study delves into the intricate realm of ICT-driven E-Learning in Tertiary Education, focusing on Nigeria as a unique context. Drawing insights from global experiences, the study explores the theoretical foundations, best practices, case studies, current trends, challenges, and future innovations in ICT integration. The study identifies critical factors influencing successful ICT integration, emphasizing the importance of adequate funding, teacher training, and supportive policies. It delves into the evolution of E-Learning, discussing its transformation from computer-based systems to online platforms, Massive Open Online Courses (MOOCs), and adaptive learning technologies. The research emphasizes the role of emerging technologies like Artificial Intelligence (AI), Virtual Reality (VR), Augmented Reality (AR), and Blockchain in reshaping the future of tertiary education. Furthermore, the study highlights the significance of user attitudes, infrastructure development, and continuous professional development for educators as pivotal areas for improvement. The study provides valuable insights for policymakers, educators, and stakeholders through in-depth analysis of best practices and case studies. By addressing challenges and embracing innovations, tertiary institutions can create a future-ready educational landscape that caters to diverse learning needs, fosters collaboration, and prepares students for the demands of the digital age. This study serves as a roadmap for transforming tertiary education in Nigeria and similar contexts, ensuring a holistic and inclusive learning experience for all.