International air quality indexes (AQIs) are derived from air pollution and are essential global tools for mitigating diseases such as asthma, as they are used to reduce exposure to triggers. The aim of this article is to systematically review the global literature on the use of AQIs in asthma-related studies. To evaluate the importance of the variables considered, a citation frequency index (Q) was used. The results suggest that the most frequently reported air pollutants related to asthma are PM (Q3) > NO2 (Q3) > O3 (Q3) > CO (Q3) > NO (Q3) > SO2 (Q3). In addition, climate variables play a relevant role in asthma research. Temperature (Q4) emerged as the most relevant climate variable, followed by atmospheric pressure (Q3) > wind direction (Q3) > solar radiation (Q3) > precipitation (Q3) > wind speed (Q3). AQIs, specifically the U.S.EPA Air Quality Index and the Air Quality Health Index, are directly associated with air pollution and the prevalence, severity and exacerbation of asthma. The findings also suggest that climate change presents additional challenges in relation to asthma by influencing the environmental conditions that affect the disease. Finally, this study provides a comprehensive view of the relationships among air quality, air pollutants and asthma and highlights the need for further research in this field to develop public health policies and environmental regulations.