Use of appropriate research methodology among authors is essential to produce high quality research. Practical operability or smooth implementation of research methodology and methods must be maintained because lapses in the implementation may hamper research and quality. Hurdles experienced by authors in the operability of research design may negatively impact the conclusions. Researchers need to be aware about the issues arising during the process of research and they must adopt certain steps to avoid such issues. The current study explored the hurdles, negative impacts and relevant measure to streamline the operability of research process. The current empirical research used qualitative design. Interview method was used for exploring author’s views. Pakistani LIS authors were selected for interview from those who have published more than one article during the period 2001 and 2016. Majority of the respondents experienced hurdles in the operability of selected research methodology. Few respondents faced problems because they selected inappropriate research method for the research problem, questions or phenomenon. Selection of irrelevant population and faulty sampling also create disturbances in the smooth execution of research process. Use of faulty data collection tool resulted in the collection of irrelevant, meaningless, neutral, or over rated data. Lack of access to data and its inventory nature and complexity of data analysis procedure also affected smooth operability. Hurdles created negative impact on the quality of research and compromised the accuracy, reliability and validity of results. Multiple strategies were proposed by authors to avoid such hurdles. The current study is an effort to help authors gain an understanding for better implementation and subsequently to make more informed decisions for selection of research methodology and methods.