Integrated processes for design and fabrication have guided mass customization of architectural systems and components. Providing affordable and accessible housing, a vital segment of the building industry, is a multifaceted process that witnessed various manifestations towards individualization over the past few decades. Design flexibility in housing systems is becoming a crucial aspect, informed by consumers’ lifestyles, demographic patterns, and lifecycles change at a rapid pace. As the housing market demands more personalized, efficient, and agile strategies, prefabricated building systems have always presented a viable alternative for flexibility and customization, following a rise of interest in the last decade focused on new modes of digitized design and production. This paper presents an overview and appraisal of various practices to implement customization in the housing industry, with specific focus on empowering a systemic approach. We then propose an open framework that could accommodate emergent design technologies and production protocols, with the aim of taking advantage of advanced research efforts, and coupled with current industry application.