Background: Decision making modalities for cancer screening for many conditions and different stages have become increasingly complex. Reengineering of traditional and paper-based decision support information system as an innovation strategy facilitates scheduling and decision making and support the delivery of cancer screening services. Objectives: The aim of study is to business process reengineering based on decision support information system in order to integration of colorectal cancer screening plan in Iranian population. Methods: The research method used in this study is mix method research (MMR) which combines quantitative methods and qualitative methods. Data collection techniques and tools in this study are: (1) Situational analysis method by checklist. The status of the current information system was evaluated with a checklist and (2) interview and focus group discussion; it is based on the 37 views of experts. Results: In this study, present screening information system was surveyed of six dimensions. These dimensions were general specification, functions, technologies, data resources, users, manual and standards of screening information system. The present information system performed only 25.1% of the expected information system tasks. The next step, conceptual models of integrated CRC screening information system are developed and approved by experts. Conclusions: Reengineering is a powerful and significant change strategy that can bring quality improvements in decision making processes of colorectal cancer screening plan. Therefore, to support the successful reengineering of decision support information system, comprehensive survey of infrastructures is needed in order to improve the quality of colorectal cancer screening plan.