Information Flow between Parents and Offspring Is Essential for Successful Development

Holt, William V.; Gadea, Joaquin

doi:10.3390/biom13091299

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Increased gray matter volume may be a compensatory mechanism [40] in an attempt to cope with multiple hypoxic events. The brain is a highly complex organ, and different regions may respond to physiological and environmental changes in different ways [41]. Therefore, the increase in gray matter volume and the change in ALFF values may not be consistent, as they may reflect different strategies and adaptive responses of the brain in the face of factors such as OSA.…”

Section: Brain Regions With Altered Gmv Valuesmentioning

confidence: 99%

Genes Associated with Altered Brain Structure and Function in Obstructive Sleep Apnea

Huang,

Shen,

Zhao

et al. 2023

Biomedicines

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Obstructive sleep apnea (OSA) has been widely reported to cause abnormalities in brain structure and function, but the genetic mechanisms behind these changes remain largely unexplored. Our research aims to investigate the relationship between sleep characteristics, cognitive impairments, genetic factors, and brain structure and function in OSA. Using structural and resting-state functional magnetic resonance imaging data, we compared cortical morphology and spontaneous brain activity between 28 patients with moderate-to-severe OSA and 34 healthy controls (HCs) utilizing voxel-based morphology (VBM) and the amplitude of low-frequency fluctuations (ALFF) analyses. In conjunction with the Allen Human Brain Atlas, we used transcriptome-neuroimaging spatial correlation analyses to investigate gene expression patterns associated with changes in gray matter volume (GMV) and ALFF in OSA. Compared to the HCs, the OSA group exhibited increased ALFF values in the left hippocampus (t = 5.294), amygdala (t = 4.176), caudate (t = 4.659), cerebellum (t = 5.896), and decreased ALFF values in the left precuneus (t = −4.776). VBM analysis revealed increased GMV in the right inferior parietal lobe (t = 5.158) in OSA. Additionally, functional enrichment analysis revealed that genes associated with both ALFF and GMV cross-sampling were enriched in gated channel activity and synaptic transmission, glutamatergic synapse, and neuron.

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Section: Brain Regions With Altered Gmv Valuesmentioning

confidence: 99%

Genes Associated with Altered Brain Structure and Function in Obstructive Sleep Apnea

Huang,

Shen,

Zhao

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Information Flow between Parents and Offspring Is Essential for Successful Development

Abstract: Over the last several decades, the sciences of developmental biology and physiology have expanded and intertwined their scope enormously [...]

Cited by 1 publication

References 17 publications

Genes Associated with Altered Brain Structure and Function in Obstructive Sleep Apnea

Genes Associated with Altered Brain Structure and Function in Obstructive Sleep Apnea

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