Information is a concept not easily penetrated in science when this refers to the involved mechanisms in the body structuration and functionality. Limited only to describing the genetic info-activity, a general coherent approach and modeling of the human organism and of the composing eukaryotic cells has not yet been explored, so this chapter is dedicated to this issue. For this, the concept of matter-related information, operating by structuration/destructuration mechanisms typical for living structures, is defined. This allows us to approach/describe the body structuration and functionality in relation to the mind and consciousness, independently on the informational sources and their nature, and to reveal a similar informational system at the human/eukaryotic composing cell level, referred to as metabolism, genetic transmission/info-generation, info-selectivity, and cognitive/sentience/decisional processes, well supported in animals, plants, and micro-organisms (bacteria) by the experimental data.