We show that the notion of the maximum force conjecture F 1/4 in general relativity, when applied to asymptotically flat singly spinning Myer-Perry black holes in any dimension, reveals the underlying thermodynamic instability in a number of ways. In particular, the "Hookean force law" F1 = kx, suitably defined, is bounded by the conjectured limit, but in d 6 it is further bounded by a dimensional dependent value less than 1/4, which remarkably corresponds to the Emparan-Myers fragmentation (splitting of a black hole into two becomes thermodynamically preferable). Furthermore, we define another "force" as the square of the angular momentum to entropy ratio (F2 = J 2 /S 2 ). In dimensions d 6, the positive Ruppeiner scalar curvature region in the thermodynamic phase space is marked by the upper boundary F2 = 1 12 d−3 d−5 and the lower boundary F2 = 1 4 d−3 d−5, the latter corresponds to a black hole that suffers from Gregory-Laflamme instability. Surprisingly, the upper and lower boundaries correspond to F = 1/4 when d = 6 and d → ∞, respectively. We discuss how the maximum force may be relevant to the underlying black hole microstructure and its relationship to cosmic censorship.