In the field of production management, decision support systems (DSS) equipped with machine learning (ML) have significantly advanced production planning and control within manufacturing companies. These systems are crucial, particularly in the machinery industry, for predicting shortages such as missing parts at the start of assembly. However, current ML-based DSS typically focus solely on predicting occurring problems or suggesting options for simplified scenarios, often missing the critical integration of human operators in the decision-making loop. This study introduces an advanced DSS that integrates ML to predict a missing part for the assembly start and to automatically provide a clear indication of the causes behind predicted shortages. This is achieved by employing shapley additive explanations (SHAP) to the respective ML-based prediction model. Thus, this analysis enables production controllers to initiate both proactive and/or reactive actions by detailed insights into the system’s predictions, and fostering a more dynamic interaction providing between human decision-makers and automated systems. This integration reduces the reliance on time-consuming manual analyses and enhances transparency in decision-making processes. The efficacy of the integrated approach is demonstrated by a case study conducted at a German machinery manufacturer, specialized in low-volume, high-variety production. The findings of this case study confirm that the DSS is efficacious in supporting complex decision-making processes, making it a valuable tool for modern production environments.