In this paper, we are proposing a bio-inspired location management (LM) technique for personal communication system (PSC). It is based on artificial immune system (AIS), with self-adaptation and self-update attributes to perform the location management, and helps to achieve better quality of service (QoS) and quality of experience (QoE) for the mobile users. Here, we are suggesting a modified mobile switching center (MSC) architecture, and an adaptive self-modified location management procedure. The proposed mobile switching center architecture has an advantage of rule-based and fact-based system to store the rules and facts related to location management procedure, and it shows the intelligent behavior of system. The mobile switching center calculates the best method for location management and the rule-based system trigged the rules to perform the techniques. The system stores the result (techniques for location management) in fact-based system for future use. The efficiency and effectiveness of the proposed techniques have been analyzed, and it observed that the proposed system has 45-50% improvement in performance over the current location management techniques. Here, we are using performance parameters such as signaling cost, database update cost, overhead measurement, and mobility management cost.