This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the effectiveness of telephone interventions, delivered by healthcare professionals, when compared to usual care or non-telephone-based support interventions for educating and psychosocially supporting informal carers of people with acute and chronic diagnosed illnesses, on these carers' quality of life, psychosocial and physical well-being. We aim, additionally, to evaluate the cost-effectiveness of telephone interventions