Small businesses are often considered important to a nation’s economy. In Nigeria, the small business sector contributes about 48% to the GDP, and there is an increasing effort to support the small business sector as a way of combatting societal ills. Within the last decade, there has been a global increase in the use of e-business by both large and small companies. Today, it is generally acknowledged that e-business provides a range of opportunities for small businesses to operate and compete effectively; however, in developing countries such as Nigeria, there is very limited research on e-business adoption in the small business sector. This thesis examines the adoption of e-business technologies and processes in Nigerian small businesses. Using an inductive approach, informed by a case study strategy, a longitudinal study of six small businesses in Lagos, Nigeria was conducted. Data was collected using interviews and questionnaires, and both thematic analysis and framework analysis were utilised to analyse the cases. Research results indicate that small businesses in Nigeria are utilising e-business systems. Key issues impacting upon e-business adoption and eight critical influencing factors that affect adoption were identified. Based on the case study findings, a framework for the development and implementation of e-business strategy in the Nigerian small business sector was developed and validated. This framework will be of value to small business owners involved in e-business operations, and also provides a basis for follow-up research in developing world countries.