Information Theoretical Analysis of Aging as a Risk Factor for Heart Disease

Blokh, David; Stambler, Ilia

doi:10.14336/ad.2014.0623

Cited by 20 publications

(10 citation statements)

References 37 publications

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“…Increased age is the predominant risk factor for several major human pathologies, including cancer, diabetes, cardiovascular disease and neurodegeneration [ 1–5 ]. Long considered an inevitable consequence of life, recent advances have revealed that aging has an underlying biological process, influenced by both genetic and environmental factors [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Ras signaling in aging and metabolic regulation

Slack

2017

Nutrition and Healthy Aging

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Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense focus as potential cancer treatments. In both invertebrate and mammalian models, emerging evidence has also implicated components of the Ras signaling pathway in aging and metabolic regulation. Here, I review the current evidence for Ras signaling in these newly discovered roles highlighting the interactions between the Ras pathway and other longevity assurance mechanisms. Defining the role of Ras signaling in maintaining age-related health may have important implications for the development of interventions that could not only increase lifespan but also delay the onset and/or progression of age-related functional decline.

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Section: Introductionmentioning

confidence: 99%

Ras signaling in aging and metabolic regulation

Slack

2017

Nutrition and Healthy Aging

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“…Patients' age could also be a factor. As one of the biomarkers of CVDs, age has the highest effect on CVDs' progression among the non-specific parameters (10). It is obvious that the risk of developing and sustaining CVDs increases with age (1) and this issue illustrates the necessity of study-ing the views and attitudes of patients of various ages on their disease.…”

Section: Introductionmentioning

confidence: 99%

Aging is an Important Cause for a Lack of Understanding of the Main Risk Factor in Cardiac Rehabilitation Patients

Komasi

Saeidi

2015

Thrita

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Background: Age, one of the key biomarkers among the nonclinical parameters of cardiovascular diseases (CVDs), has the greatest effect on the development and progression of CVDs. Objectives: The current study was done to evaluate the effect of age on cardiac rehabilitation (CR) patients' attitudes regarding the main cause of their condition. Patients and Methods: The administrative data of this cross-sectional study were obtained from the database of the CR department of a hospital in Iran. The demographic and clinical information of 901 patients was obtained from January 2004 and January 2012 using compiled forms of this database and the structured clinical interview for Axis I Disorders (SCID-I). Univariate analysis of variance and Bonferroni post-hoc analysis were used for the data analysis. Results: After adjusting for gender, it was revealed that significant age differences existed between patients who perceived no specific risk factors (62.43 years) and those who viewed biological (55.0), physiological (57.31), behavioral (57.85), and psychological (57.25) risk factors as the main cause of their condition (P < 0.05). The age differences between those who had no perceived risk factors (62.43) was significantly different from patients perceiving biological (55.0) and environmental (62.03) factors to be the main cause (P < 0.05). Conclusions: Although older patients need more self-care and the quality of this self-care originates from their attitude toward CVD risk factors, their lack of awareness about the main risk factor of their condition is a major challenge for secondary prevention measures. In addition, younger patients' significant emphasis on biological risk factors as uncorrectable factors can reduce their sense of responsibility toward attempting to control correctable risk factors. Correcting these patients' attitudes regarding CVD risk factors can result in better responsibility feeling by the patients and can improve treatment outcomes.

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“…Individual biomarkers may not be indicative of the process or state of degeneration, and need to be considered in combinations, or ideally in a systemic balanced way - otherwise interventions on particular biomarkers and pathways may exacerbate other biomarkers and pathways, and disrupt the system as a whole. The general methodology for the evaluation of the effects of multiple risk factors (including biomarkers of aging) on multiple age-related diseases (multimorbidity) need to be improved, to allow the evaluation of non-linear, cumulative or synergistic effects [ 31 , 42 , 43 ].…”

Section: Methodological Challengesmentioning

confidence: 99%

Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy

Stambler¹

2017

Aging and disease

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It is becoming increasingly clear that in order to accomplish healthy longevity for the population, there is an urgent need for the research and development of effective therapies against degenerative aging processes underlying major aging-related diseases, including heart disease, neurodegenerative diseases, type 2 diabetes, cancer, pulmonary obstructive diseases, as well as aging-related complications and susceptibilities of infectious communicable diseases. Yet, an important incentive for the research and development of such therapies appears to be the development of clinically applicable and scientifically grounded definitions and criteria for the multifactorial degenerative aging process (or “senility” using the existing ICD category), underlying those diseases, as well as for the safety and effectiveness of interventions against it. Such generally agreed definitions and criteria are currently absent. The devising of such criteria is important not only for the sake of their scientific value and their utility for the development of therapeutic solutions for the aging population, but also to comply with and implement major existing national and international programmatic and regulatory requirements. Some methodological suggestions and potential pitfalls for the development of such criteria are examined.

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Information Theoretical Analysis of Aging as a Risk Factor for Heart Disease

Cited by 20 publications

References 37 publications

Ras signaling in aging and metabolic regulation

Ras signaling in aging and metabolic regulation

Aging is an Important Cause for a Lack of Understanding of the Main Risk Factor in Cardiac Rehabilitation Patients

Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy

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