Information transmission by isolated frog muscle spindle

Firing pattern of skeletomotor neurones innervating triceps surae muscles in response to pseudo-random muscle stretching and white noise modulated transmembrane current stimulation was investigated in decerebrate cats. Pseudo-random muscle stretching (upper cut-off frequency 60 Hz, amplitude sigma (standard deviation) ranging from 18.5 microns to 40 microns) was applied to triceps surae muscles. Membrane potential changes and action potentials of skeletomotor neurones were recorded intracellularly. White noise modulated current was applied through the same (recording) microelectrode. Sequences of ten identical 5 s periods of either muscle stretching or transmembrane current stimulation were applied. Skeletomotor neurones belonging to slow motor units (rheobase less than 8.5 nA) generated action potentials in response to both pseudo-random muscle stretching and transmembrane current stimulation, while firing threshold of those belonging to fast motor units could not be reached by the muscle stretches applied. Peri-spike averaging of muscle length and injected current records showed that the action potentials appeared at the peak of either depolarizing current wave or muscle stretching both preceded by a change in opposite direction (the spikes coinciding with the peak in muscle length PSA being actually elicited by muscle spindle action potentials triggered at the moment of the peak stretching velocity). Time coupling of action potentials occurred during both muscle stretching and transmembrane stimulation, being more tight in the latter case as well as when larger amplitudes of the stimuli were applied.(ABSTRACT TRUNCATED AT 250 WORDS)

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Time coupling of skeletomotor discharges in response to pseudo-random transsynaptic and transmembrane stimulation

Anastasijević

Jovanovic

Ljubisavljević

et al. 1991

Biol. Cybern.

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Information theory in neuroscience

2011

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Influence of 14-day hind limb unloading on isolated muscle spindle activity in rats

Zhao

Fan

Xiao

et al. 2010

J Muscle Res Cell Motil

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During hind limb unloading (HU), the soleus is often in a shortened position and the natural physiological stimulus of muscle spindles is altered, such that muscle spindle activity also changes. Using isolated spindle conditions, the present study investigates the electrophysiological activity and ultrastructure of muscle spindles following HU. Results show that muscle spindle discharges fall into either of two main patterns, single spikes or spike clusters in shortened positions, with a steady frequency of 18-38 spikes/s (mean 29.08 +/- 2.45) in an extended position. Following 14-day HU, afferent discharge activity was significantly altered in soleus muscle spindles. Duration of individual spikes was significantly prolonged, from 0.54 +/- 0.05 ms for control rats to 1.53 +/- 0.25 ms for rats in the HU group. In a shortened position, regular rhythm afferent discharges were obviously depressed, and the majority of muscle spindles became silent, while in an extended position, the discharges remained continuous but with decreased frequency. Results also show that the ultrastructure of muscle spindles experience degenerative changes during HU. Altered muscle spindle afference could possibly modify the activity of motor neurons and further affect the activity of extrafusal fibers.

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Information transmission by isolated frog muscle spindle

Cited by 6 publications

References 76 publications

Time coupling of skeletomotor discharges in response to pseudo-random transsynaptic and transmembrane stimulation

Time coupling of skeletomotor discharges in response to pseudo-random transsynaptic and transmembrane stimulation

Information theory in neuroscience

Influence of 14-day hind limb unloading on isolated muscle spindle activity in rats

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