Infrainguinal revascularizations in octogenarians and septuagenarians

Chang, John B.; Stein, Theodore A.

doi:10.1067/mva.2001.113979

Cited by 36 publications

(35 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When need for TER was not considered, the secondary clinical success rates were also similar between age groups, with no difference in the Ն80 groups between endovascular and open groups. These results were somewhat better than the recent study by Brosi et al, 8 and similar to the primary clinical success of 64% to 79% in other reports, 3,10,11 although the criteria were not as strict in those studies.…”

Section: Discussionsupporting

confidence: 88%

“…27,28 We found that in the Ն80 group, patients who underwent endovascular revascularization for the treatment of CLI had a significantly lower mortality rate at 3.1%, similar to the previously reported 2% to 12%. [2][3][4]8,10 The limb salvage rates in open treatment groups were similar between the two age groups, however, the LS rate was significantly better in the Ն80 group who had endovascular revascularizations than those Ͻ80 years, which remained valid even when dialysis patients in the Ͻ80 group were excluded. To our knowledge, this is the first study reporting superior LS rates in octogenarians than nonoctogenarians with endovascular interventions.…”

Section: Discussionmentioning

confidence: 97%

“…1 Several studies suggest that comparable limb salvage can be achieved with bypass procedures in patients over 80, [2][3][4][5] which may increase survival if amputation can be avoided. 6,7 However, these studies often included patients who were ambulatory or functionally independent, and the results may not be applicable to patients over 80 years of age who present with CLI and have a limited functional capacity.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Superior limb salvage with endovascular therapy in octogenarians with critical limb ischemia

Döslüoglu

Lall

Cherr

et al. 2009

Journal of Vascular Surgery

View full text Add to dashboard Cite

Our results suggest that revascularization in patients >/=80 with CLI is justified, especially when an endovascular intervention can be accomplished. Although limb salvage following endovascular interventions were better in the >/=80 group, sustained clinical success, and secondary clinical success rates were similar following open and endovascular interventions in both age groups. Open procedures carry a high perioperative mortality in the >/=80 age group and should be avoided if possible.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

See 1 more Smart Citation

Superior limb salvage with endovascular therapy in octogenarians with critical limb ischemia

Döslüoglu

Lall

Cherr

et al. 2009

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

“…In 31 young patients, with a mean age of 44 years, the 18-month primary patency rate after a surgical intervention was 60 8 11%, and the assisted primary patency rate was 78 8 9% [19] . Among 128 femoropopliteal and 99 femorotibial bypass grafts in 209 octogenarians, and 242 femoropopliteal and 166 femorotibial bypass grafts in 383 septuagenarians, the 5-year primary patency rates were 74% for octogenarians and 68% for septuagenarians (p 1 0.2) [20] . Compared to controls, these patency rates were excellent and similar.…”

Section: Discussionmentioning

confidence: 99%

Patient Age and Patency Rate after Recanalization of Occluded Peripheral Arteries

Kröger

Strubel²,

Poser³

et al. 2004

Gerontology

View full text Add to dashboard Cite

Objectives: Due to an increase in the percentage of older people in industrialized countries there is an increasing demand for medical care for the elderly. With advancing age, a series of structural, architectural and compositional modifications take place in the vasculature. Therefore, we analyzed the influence of patient age on the reocclusion rate of recanalized peripheral arteries. Patients and Methods: 471 patients (mean age ± SD: 62 ± 12 years, range: 28–90 years) successfully treated by interventional recanalization were followed up (mean ± SD: 18 ± 17 months, range:6–48 months). Reocclusion of the recanalized arterial segment could be proven in 175 patients (37%), whereas octogenarians had the highest patency rate i.e. 68%. Univariate analysis, multivariate logistic regression analysis, and ROC analysis were performed. Results: The univariate analysis showed a significant relation between reocclusion and PAOD stage, hyperlipoproteinemia, and total cholesterol level and erythrocyte sedimentation rate (ESR), respectively. Excluding age-related risk factors, the multivariate logistic regression analysis with backward selection reached a significant level for PAOD stage with p = 0.0012 and an odds ratio of 1.63, and for ESR with a p = 0.0013 and an odds ratio of only 1.02. Age did not reach a significant level with a p value of 0.13 and an odds ratio of 0.98. In the ROC analysis, prognostic relevance could be shown for the combination of PAOD stage and ESR adjusted for age and hyperlipidemia, and for PAOD stage and ESR value as a single prognostic factor, but not for patient age. Conclusion: Thus, despite proven and hypothetical differences in the vascular biology of older people compared to younger people, age is not related to middle term patency rates after interventional recanalization of peripheral arterial occlusions.

show abstract

“…If other comorbidities such as diabetes mellitus, coronary artery, or carotid disease are present, the possibility of saving the extremity is even further reduced, because of the unacceptable risk of intra-and postoperative complications. 3 This group of patients has therefore a major amputation likelihood of 10-40%. 4 The concept of therapeutic angiogenesis emerges as a result of the search for alternative treatments for ischemic diseases such as POAD.…”

mentioning

confidence: 99%

Bone marrow mononuclear cells stimulate angiogenesis when transplanted into surgically induced fibrocollagenous tunnels: Results from a canine ischemic hindlimb model

et al. 2006

View full text Add to dashboard Cite

Progenitor cell transplantation has been considered as a potential angiogenesis therapy for the ischemic hindlimb. In this work we performed an ischemic hindlimb model in dogs. We ligated the middle sacra and the external right iliac arteries. After 7 days, the femoral artery was ligated and removed, and three Silastic tubes were inserted into the gracilis muscle to create fibrocollagenous tunnels. After Silastic implantation, we administered saline or granulocyte colony stimulating factor (G-CSF) subcutaneously daily during 5 days. Fourteen days after device positioning we transplanted bone marrow mononuclear cells (BMMC) into the tunnels previously formed by Silastic tube reaction. Twenty-eight days later, contrasted angiographies were performed and angiographic scores were calculated. Also, vessels and endothelial cells and proliferating cells were identified by immunochemistry of muscle sections. Results demonstrated that BMMC transplantation enriched by G-CSF administration significantly stimulates angiogenesis in the ischemic hindlimb, and more than BMMC transplantation alone. Transplantation of progenitor cells in an appropriate extracellular matrix is a potential therapy for hindlimb ischemia.

show abstract

Infrainguinal revascularizations in octogenarians and septuagenarians

Cited by 36 publications

References 12 publications

Superior limb salvage with endovascular therapy in octogenarians with critical limb ischemia

Superior limb salvage with endovascular therapy in octogenarians with critical limb ischemia

Patient Age and Patency Rate after Recanalization of Occluded Peripheral Arteries

Bone marrow mononuclear cells stimulate angiogenesis when transplanted into surgically induced fibrocollagenous tunnels: Results from a canine ischemic hindlimb model

Contact Info

Product

Resources

About