Infrared‐Emitting QDs for Thermal Therapy with Real‐Time Subcutaneous Temperature Feedback

Rosal, Blanca del; Carrasco, Elisa; Ren, Fuqiang; Benayas, Antonio; Vetrone, Fiorenzo; Sanz-Rodrı́guez, Francisco; Ma, Dongling; Juarranz, Ángeles; Jaque, Daniel

doi:10.1002/adfm.201601953

Cited by 124 publications

(94 citation statements)

References 57 publications

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“…Luminescent thermal reading can provide temperature measurements in inflamed regions in vivo via contactless and noninvasive luminescence bioimaging 22,23 . Recently, luminescent nanothermometry has been used to control hyperthermia in photothermal therapy, which utilizes photothermal agents to generate heat to kill cancer cells under near-infrared (NIR) laser irradiation, to minimize the damage to surrounding normal tissues [24][25][26] . Upconversion luminescence (UCL) bioimaging can reduce auto-fluorescence from biological systems owing to its anti-Stokes process [27][28][29] .…”

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confidence: 99%

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

et al. 2020

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The in vivo temperature monitoring of a microenvironment is significant in biology and nanomedicine research. Luminescent nanothermometry provides a noninvasive method of detecting the temperature in vivo with high sensitivity and high response speed. However, absorption and scattering in complex tissues limit the signal penetration depth and cause errors due to variation at different locations in vivo. In order to minimize these errors and monitor temperature in vivo, in the present work, we provided a strategy to fabricate a samewavelength dual emission ratiometric upconversion luminescence nanothermometer based on a hybrid structure composed of upconversion emissive PbS quantum dots and Tm-doped upconversion nanoparticles. The ratiometric signal composed of two upconversion emissions working at the same wavelength, but different luminescent lifetimes, were decoded via a time-resolved technique. This nanothermometer improved the temperature monitoring ability and a thermal resolution and sensitivity of~0.5 K and~5.6% K −1 were obtained in vivo, respectively.

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confidence: 99%

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

et al. 2020

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“…[4] Until now,o nly PbS/CdS/ZnS quantum dots (QDs) and lanthanide-based upconversion nanoparticles have been revealed to have such ability for realtime monitoring of temperature during PTT. [5] However,both fluorescence and up-conversion luminescence require realtime light excitation, which not only interferes the photothermal irradiation light but also compromises the imaging sensitivity due to tissue autofluorescence.M oreover,o rganic nanoparticles with intrinsic heat-reporting ability have not been reported for real-time temperature monitoring during PTT.…”

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confidence: 99%

Temperature‐Correlated Afterglow of a Semiconducting Polymer Nanococktail for Imaging‐Guided Photothermal Therapy

2018

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Nanoparticles for photothermal therapy: Real-time temperature monitoring is critical to reduce the nonspecific damage during photothermal therapy (PTT); however, PTT agents that can emit temperature-related signals are rare and limited to few inorganic nanoparticles. We herein synthesize a semiconducting polymer nanococktail (SPN ) that can not only convert photo-energy to heat but also emit temperature-correlated luminescence after cessation of light excitation. Such an afterglow luminescence of the SPN detects tumors more sensitively than fluorescence as a result of the elimination of tissue autofluorescence, while its temperature-dependent nature allows tumor temperature to be optically monitored under near-infrared (NIR) laser irradiation. Thus, SPN represents the first organic optical nanosystem that enables optical-imaging guided PTT without real-time light excitation.

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“…Mito thermo yellow and Mito-RTP [8,9] are examples of fluorescent thermometers that are able to bind to the mitochondria for fast monitoring of thermal processes related to a cell's metabolism. Other fluorescent temperature sensors include quantum dots [10][11][12] and nitrogen vacancy centres in diamond [13] which have been developed to measure point-based temperature in various chemical and biological systems with sub-micron resolution. Thermal cameras based on near infrared imaging have been used to monitor heat generation of electro-chemical processes in fuel cells [14], with a spatial resolution of ∼ 0.1mm.…”

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confidence: 99%

Micron scale thermometry using lanthanide doped tellurite glass

Stavrevski

Schartner

Abraham

et al. 2019

AOS Australian Conference on Optical Fibre Technology (ACOFT) and Australian Conference on Optics, Lasers, and Spectroscopy (AC

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Quantifying temperature variations at the micron scale can provide new opportunities in optical sensing. In this paper, we present a novel approach using the temperature-dependent variations in fluorescence of rare-earth doped tellurite glass to provide a micron-scale image of temperature variations over a 200 micrometre field of view. We demonstrate the system by monitoring the evaporation of a water droplet and report a net temperature change of 7.04 K with a sensitivity of at least 0.12 K. These results establish the practicality of this confocal-based approach to provide high-resolution marker-free optical temperature sensing.

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Infrared‐Emitting QDs for Thermal Therapy with Real‐Time Subcutaneous Temperature Feedback

Cited by 124 publications

References 57 publications

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

Temperature‐Correlated Afterglow of a Semiconducting Polymer Nanococktail for Imaging‐Guided Photothermal Therapy

Micron scale thermometry using lanthanide doped tellurite glass

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