In a wide variety of engineering applications, convection heat transfer enhancement plays a major role in reducing the heat exchanger’s size and costs and increasing their efficiency. The passive methods for increasing convective heat transfer are the most interesting since they don’t require any external power to achieve the desired enhancement. For this reason, this approach is preferred in the industrial sector of heat exchangers. For the enhancement of the performances of these apparatuses, in particular, the tubular ones used in the pharmaceutical, food, and chemical, the most adopted passive solution is the corrugation of their tube walls. Two pipes characterized by cross-helix corrugation have been experimentally analyzed both investigating the global heat transfer performance and studying the local heat transfer coefficient distribution to profoundly examine the thermal performance enhancement mechanisms of this passive technique. It has been observed that at Re = 16,000, the heat transfer rate in the smaller pitch tube is 18.18% higher than that in the larger pitch tube. The inverse heat conduction problem in the tube wall is addressed to achieve the local coefficient distribution method by using temperature readings collected from an infrared camera on the outer surface of the tube as the initial data.