Infrared Photochemistry of Gas Phase Ions

Thorne, L. R.; Wright, C. A.; Beauchamp, J. L.

doi:10.1007/978-3-642-50207-1_3

Cited by 14 publications

(8 citation statements)

References 65 publications

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“…IRMPD analyses of several small compounds have long ago been reported (Morgenthaler & Eyler, 1979;Dunbar, 1984;Thorne & Beauchamp, 1984;Bensimon, Rapin, & Gaumann, 1986;Gauthier, Trautman, & Jacobson, 1991;Dunbar et al, 1995). Studies of IRMPD of proteins have also been reported (Little et al, 1994;Dufresne, Wood, & Hendrickson, 1998).…”

Section: Infrared-multiphoton Dissociation (Irmpd)mentioning

confidence: 96%

Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides

Park

Lebrilla

2004

Mass Spectrometry Reviews

143

108

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The application of Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) to the structural elucidation of oligosaccharides is described. This review covers the analyses of oligosaccharides in the context of the unique features of FTICR MS and the improvements in instrumentation that make it possible to study this class of compounds. It consists of work performed initially to understand the fundamental aspects of oligosaccharide ionization and unimolecular fragmentation. More recent investigation includes the application of the technique to samples of direct biological origin. Chemical and enzymatic degradation methods in conjunction with mass spectrometry (MS) and the use front-end methods with FTICR MS are also discussed. The current applications including the characterization of bacterial lipooligosaccharides and phosporylated carbohydrates are described.

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Section: Infrared-multiphoton Dissociation (Irmpd)mentioning

confidence: 96%

Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides

Park

Lebrilla

2004

Mass Spectrometry Reviews

143

108

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“…Another approach uses the IRMPD (Woodin, Bomse, & Beauchamp, 1978;Thorne & Beauchamp, 1983) technique to determine the photodissociation kinetics of protonated leucine enkephalin with a continuous-wave CO 2 laser and FT-ICR (Jockusch, Paech, & Williams, 2000). First-order kinetics were fitted to the experimental data, and a master-equation simulation was performed to extract energetic information.…”

Section: A Published Dissociation Parameters Of Yggfl (Activation Enmentioning

confidence: 99%

Leucine enkephalin—A mass spectrometry standard

Sztáray

Memboeuf

Drahos

et al. 2011

Mass Spectrometry Reviews

108

118

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The present article reviews the mass spectrometric fragmentation processes and fragmentation energetics of leucine enkephalin, a commonly used peptide, which has been studied in detail and has often been used as a standard or reference compound to test novel instrumentation, new methodologies, or to tune instruments. The main purpose of the article is to facilitate its use as a reference material; therefore, all available mass spectrometry-related information on leucine enkephalin has been critically reviewed and summarized. The fragmentation mechanism of leucine enkephalin is typical for a small peptide; but is understood far better than that of most other compounds. Because ion ratios in the MS/MS spectra indicate the degree of excitation, leucine enkephalin is often used as a thermometer molecule in electrospray or matrix-assisted laser desorption ionization (ESI or MALDI). Other parameters described for leucine enkephalin include collisional cross-section and energy transfer; proton affinity and gas-phase basicity; radiative cooling rate; and vibrational frequencies. The lowest-energy fragmentation channel of leucine enkephalin is the MH(+) → b(4) process. All available data for this process have been re-evaluated. It was found that, although the published E(a) values were significantly different, the corresponding Gibbs free energy change showed good agreement (1.32 ± 0.07 eV) in various studies. Temperature- and energy-dependent rate constants were re-evaluated with an Arrhenius plot. The plot showed good linear correlation among all data (R(2) = 0.97), spanned over a 9 orders of magnitude range in the rate constants and yielded 1.14 eV activation energy and 10(11.0) sec(-1) pre-exponential factor. Accuracy (including random and systematic errors, with a 95% confidence interval) is ±0.05 eV and 10(±0.5) sec(-1), respectively. The activation entropy at 470 K that corresponds to this reaction is -38.1 ± 9.6 J mol(-1) K(-1). We believe that these re-evaluated values are by far the most accurate activation parameters available at present for a protonated peptide and can be considered as "consensus" values; results on other processes might be compared to this reference value.

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“…Another approach uses the IRMPD (Woodin, Bomse, & Beauchamp, 1978; Thorne & Beauchamp, 1983) technique to determine the photodissociation kinetics of protonated leucine enkephalin with a continuous‐wave CO 2 laser and FT‐ICR (Jockusch, Paech, & Williams, 2000). First‐order kinetics were fitted to the experimental data, and a master‐equation simulation was performed to extract energetic information.…”

Section: Energetics Of the Mh+ → B4 Processmentioning

confidence: 99%

Candida Cholecystitis in a Diabetic Patient on Chronic Peritoneal Dialysis

Weng

Chang

Lin

et al. 2008

Dialysis & Transplantation

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To examine the antiparkinsonian effects of blocking glycineB receptors, we designed a pilot study testing the potent and selective antagonist, PAMQX, in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐treated primates. PAMQX had no intrinsic effects but markedly potentiated the antiparkinsonian action of levodopa. In a dose‐dependent fashion, coadministration of the glycineB antagonist with levodopa extended the response duration by nearly 60%. It is noteworthy that PAMQX, within a considerable dose range, did not cause ataxia or other side effects. These data indicate that blocking N‐methyl‐D‐aspartate receptors selectively to manipulate dopaminergic‐mediated motor responses may be produced effectively by glycineB antagonists. Ann Neurol 2004

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Infrared Photochemistry of Gas Phase Ions

Cited by 14 publications

References 65 publications

Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides

Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides

Leucine enkephalin—A mass spectrometry standard

Candida Cholecystitis in a Diabetic Patient on Chronic Peritoneal Dialysis

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