In this paper, a novel infrared maritime small target detection method, called local dissimilarity measure with antiinterference based on global graph clustering (LDMGGC), is proposed. The Wasserstein distance is introduced to calculate the dissimilarity of gray level distribution between a central region and its neighborhoods. These dissimilarities construct the feature of a region. With this feature, detection for recalling all suspected targets is achieved. As the maritime interferences among suspected targets are able to be clustered, relaxing mutual k nearest neighbor graph is introduced in global graph clustering for filtering interferences. With this method, real targets are detected and maritime interferences are filtered out. Experiments are conducted on three maritime datasets and a non-maritime dataset for comparison. On three datasets, the proposed method achieves the best Receiver Operating Characteristic curves and Area Under Curve (0.99529, 0.99945, 0.99573, and 0.9906) values, meaning that the proposed method has high detection probability and low false-alarm ratio. Target Hit Rate (98.04%, 97.96%, 100%, and 99.24%) and Intersection of Union (0.8170, 0.7542, 0.5824, 0.7707) on four datasets of the proposed method show it has a strong ability to suppress the interferences.