Infrared spectroscopic studies of protein formulations containing glycine

Meyer, Jeffrey D.; Bai, Shu Jun; Rani, Meena; Suryanarayanan, Raj; Nayar, Rajiv; Carpenter, John F.; Manning, Mark C.

doi:10.1002/jps.20019

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…Shifts of peaks of amorphous material can also vary markedly from the corresponding crystalline peaks. The FTIR results are in accordance with the literature data [15,30] but are not sensitive enough to significantly aid to the unambiguous data interpretation. FTIR analysis is more useful for investigation of the transition of β-glycine to α-glycine.…”

Section: Resultssupporting

confidence: 91%

“…Even though the literature [21][22][23][24][25][26] often stated that the spray drier produces amorphous powders, spray drying of the aqueous solutions of all examined salts results with purely crystalline products. According to the results of Meyer et al [30] the FTIR absorbance spectra appear to be different for amorphous and crystalline glycine. Amorphous peaks are much broader than crystalline peaks, due to the disorder inherent in the amorphous phase [29].…”

Section: Resultsmentioning

confidence: 80%

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Crystallization of β‐glycine by spray drying

Sander

Penović

Šipušić

2011

Cryst. Res. Technol.

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Glycine crystallization during spray drying has been investigated on a laboratory scale. In order to obtain different polymorphs the experiments have been performed at different hot air temperatures, concentrations, different flow of the solution and spraying air. The obtained crystals were analyzed by means of X-ray powder diffractometry, differential scanning calorimetry and the Fourier transform infrared spectrometry. Crystallization mostly resulted with a mixture of α-and β-glycine with a small amount of γ-glycine. The glycine polymorphism is affected by the drying air temperature, concentration and the flow of the solution, as well as the spraying air flow. Decrease of the drying air temperature and increase of the solution flow rate causes the increase of the quantity of β-glycine. At room conditions, β-glycine spontaneously transforms into thermodynamically more stable α-glycine.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 80%

Crystallization of β‐glycine by spray drying

Sander

Penović

Šipušić

2011

Cryst. Res. Technol.

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“…17, 18 Each technique has its own strengths and limitations, including: a relatively high limit of detection for XRPD (>~1% typically), 5, 19 long analysis times for NMR, 16 interference by excipients and subsampling with Raman, 13, 20, 21 relatively small fields of view and the inability to probe sub-surface details for SEM. 1,7,10,22 Consequently, sensitive detection of crystallinity at low loadings deep within tablets and powders represents an important niche not easily addressed by existing common methodologies.…”

Section: Introductionmentioning

confidence: 99%

Selective Imaging of Active Pharmaceutical Ingredients in Powdered Blends with Common Excipients Utilizing Two-Photon Excited Ultraviolet-Fluorescence and Ultraviolet-Second Order Nonlinear Optical Imaging of Chiral Crystals

Toth

Madden²,

Taylor³

et al. 2012

Anal. Chem.

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Second order nonlinear optical imaging of chiral crystals (SONICC) and two-photon excited fluorescence measurements [both autofluorescence and two-photon excited UV-fluorescence (TPE-UVF)] were assessed for the selective detection of APIs relative to common pharmaceutical excipients. Active pharmaceutical ingredients (APIs) compose only a small percentage of most tabulated formulations, yet the API distribution within the tablet can affect drug release and tablet stability. Complementary measurements using either UV-SONICC (266 nm detection) or TPE-UVF were shown to generate signals >50-fold more intense for a model API (griseofulvin) than those produced by common pharmaceutical excipients. The combined product of the measurements produced signals >10 4 -fold greater than the excipients studied. UV-SONICC or TPE-UVF produced greater selectivity than analogous measurements with visible-light detection, attributed to the presence of aromatic moieties within the API exhibiting strong one and two photon absorption at ~266 nm. Complementary SONICC and fluorescence measurements allowed for the sensitive detection of the three-dimensional distribution of tadalafil within a Cialis ® tablet to a depth of >140 µm.

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“…4). 25 A reference region was identified using a peptide/polymer sample, a polymer sample and a sample of peptide alone (Fig. 4).…”

Section: Resultsmentioning

confidence: 99%