Infrared-Spectroscopy: A Non-Invasive Tool for Medical Diagnostics and Drug Analysis

Abstract

Constant development enabled Infrared (IR) spectroscopy to become a widely used, non-invasive tool for fast sample analyses with less to no pre-preparation. Furthermore, computational data handling is no more a limiting factor and hence, IR measurements are predestined for clinical diagnostics and drug analysis. Within this review the focus was put on clinical topics of high interest. One example is Alzheimer's disease, where the exact metabolism is still not clarified, or blood glucose monitoring for high throughput screening of patients without taking any drop of blood. The second section of this manuscript was focused on the analysis of drugs. The detection of physico-chemical parameters in pharmaceutics and the improvement of industrial proceedings allowed a dramatic increase of quality of produced medicine. In pharmaceutical industries problems with the equable allocation of agents occurs especially in scaling up processes. IR-analyzing-techniques serve as fast and precise indicators for the detection of active components and their distribution in tablets. In combination with statistical factors and medical investigations pharmaceuticals can be improved from their development until their application, and every step can be easily controlled by IR spectroscopy.

Application of Fourier transform infrared spectroscopy to biomolecular profiling of cultured fibroblast cells from Gaucher disease patients: A preliminary investigation

“…FTIR spectroscopy has already been used in medical diagnostics for some diseases as an alternative to well-known biochemical and histochemical methods and it is suitable for routine use. 28,29 The present study was a complementary investigation to our ongoing proteomic analyses of GD and allowed us to carry our reserarch from the proteomic level to metabolomics in the biology systems frame. We attempted to introduce and apply FTIR spectroscopy to make molecular characterization of GD and our results showed that the application of this technique in GD research deserves further investigation to assess its potential in the diagnosis and monitoring of GD.…”

Assessment of the main plasma parameters included in a metabolic profile of dairy cow based on Fourier Transform mid-infrared spectroscopy: preliminary results

“…However, some critical aspects can restrict its use, including the cost of analytical testing and in some cases the long waiting time between the sampling and return of analysis results. Human studies have demonstrated the potential of infrared spectroscopic methods for reliable clinical chemistry [ 11 , 12 ], as well as clinical applications and diseases diagnosis [ 13 ].…”

Conformational Stability and Vibrational Relaxation as a Function of Halogen Substitution in Benzene sulfonamides: A Theoretical Study

“…[22] These modes serve as fast, precise indicators for detecting active components and their distribution in pharmaceutical drug development and production. [23] The chemical structure dictates the biologically relevant properties of molecules. Therefore, vibrational signatures have been identified to probe the structure of drugs.…”

“…Investigating vibrational modes is also useful for identifying drug‐binding sites [22] . These modes serve as fast, precise indicators for detecting active components and their distribution in pharmaceutical drug development and production [23] . The chemical structure dictates the biologically relevant properties of molecules.…”