2019
DOI: 10.1134/s1990519x19020093
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Infrared Spectroscopy of Blood Serum from Patients with Multiple Myeloma

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Cited by 12 publications
(7 citation statements)
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“…This change of the system is caused by the fact that a change in conformation (secondary structure) of BS albumins and immunoglobulins takes place in patients [24,25]. The later circumstance, as shown above, can result in partial dimerization of serum proteins [26,27]. As a consequence, dipole moments of proteins and their dimers change towards their increase.…”
Section: G(τ)mentioning
confidence: 97%
See 1 more Smart Citation
“…This change of the system is caused by the fact that a change in conformation (secondary structure) of BS albumins and immunoglobulins takes place in patients [24,25]. The later circumstance, as shown above, can result in partial dimerization of serum proteins [26,27]. As a consequence, dipole moments of proteins and their dimers change towards their increase.…”
Section: G(τ)mentioning
confidence: 97%
“…The detected features of donor and patient DS, that is the conductivity decrease in the region of high frequencies, as well as the correlation between the power exponent s and the total protein content, and changes in the spectrum of relaxation complexes responsible for relaxation in the region of low frequencies indicate the change in quantitative relationship between blood components in the case of disease. This change of the system is caused by the fact that a change in conformation (secondary structure) of BS albumins and immunoglobulins takes place in patients [24,25]. The later circumstance, as shown above, can result in partial dimerization of serum proteins [26,27].…”
Section: G(τ)mentioning
confidence: 97%
“…Первичную обработку и анализ спектров проводили с помощью программного обеспечения, поставляемого с прибором, в соответствии с описанной ранее методикой [22,23]. Как уже отмечалось выше, форма полосы Амид I весьма чувствительна ко вторичной структуре белков [20]. В связи с тем, что развитие ММ сопровождается существенным изменением белкового состава сыворотки крови [8][9][10], анализ полосы Амид I позволяет выявлять статистически значимые различия в средних значениях основных параметров вторичной структуры белков в составе сыворотки пациентов с диагнозом ММ и здоровых доноров [18,28].…”
Section: ик спектроскопияunclassified
“…В связи с этим возникает необходимость в поиске новых простых и доступных методик первичного скрининга широкого круга пациентов с целью выявления признаков развития ММ. Одним из перспективных инструментов для выявления различных патологий может выступать инфракрасная (ИК) спектроскопия [15][16][17][18][19][20]. В настоящей работе проведен сравнительный анализ ИК спектров сыворотки крови больных множественной миеломой и здоровых доноров.…”
Section: Introductionunclassified
“…During last years, Fourier Transform Infrared (FTIR) micro-spectroscopy has been widely used to investigate different types of biomedical samples, as tissues [1][2][3], biological fluids [4][5][6], and cells [6][7][8][9]. One of the main biomedical applications of FTIR micro-spectroscopy concerns the possibility to discriminate cancer cells from their normal counterpart according to specific spectral changes.…”
Section: Introductionmentioning
confidence: 99%