Infrared Thermographic Screening of Combinatorial Libraries of Heterogeneous Catalysts

Moates, F. Craig; Somani, Mahesh C.; Annamalai, J.; Richardson, James T.; Luss, Dan; Willson, Richard C.

doi:10.1021/ie960476k

Cited by 212 publications

(107 citation statements)

References 5 publications

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“…The combinatorial method entails the synthesis of large libraries of compounds, in which composition or processing conditions are systematically varied, followed by screening for a particular property of interest. Recently, this approach has been used with some success in the discovery of new catalysts [3][4][5][6], and sophisticated methods for rapid screening of catalyst libraries have now been developed [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Combinatorial discovery of bifunctional oxygen reduction — water oxidation electrocatalysts for regenerative fuel cells

2001

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Section: Introductionmentioning

confidence: 99%

Combinatorial discovery of bifunctional oxygen reduction — water oxidation electrocatalysts for regenerative fuel cells

2001

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“…Existem quatro estratégias principais de síntese para a produção de um conjunto de amostras 5,[16][17][18][19][20][21] : síntese paralela, "split and mix", síntese via "thin-film vapor deposition" e a síntese via "ink jet".…”

Section: Metodologias De Sínteseunclassified

“…Então, métodos analíticos rápidos estão sendo desenvolvidos por muitos grupos de pesquisa. Baseiam-se no uso de ferramentas analíticas otimizadas, automatizadas e de leituras simultâneas, como a microdifração de raios X, cromatografia e termografia, dentre outras [16][17][18][19][20][21] .…”

Section: Síntese Paralelaunclassified

“…Métodos para a química combinatória aplicada a materiais estão em desenvolvimento muito rápido e estratégias experimentais adequadas a cada metodologia estão aparecendo também rapidamente 5,11,[15][16][17][18][19] . Uma das grandes limitações para a aplicação desta abordagem, de maneira mais abrangente, consiste no desenvolvimento de técnicas analíticas automatizadas que permitam obter, de forma rá-pida e confiável, informações relevantes sobre o sistema em estudo.…”

Section: Conclusãounclassified

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Química combinatória de materiais com análise por microdifração de raios X. Primeira parte: fundamentos

Estrada¹,

Manoel

Garrido

et al. 2005

Quím. Nova

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“…Recently, combinatorial methods have been applied within several different areas of materials science, where increasing compositional or structural complexity often results in unique or otherwise improved properties (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Structural and compositional complexity may result in systems consisting of several components functioning cooperatively.…”

mentioning

confidence: 99%

Combinatorial discovery of oxidative dehydrogenation catalysts within the Mo-V-Nb-O system

Cong¹,

Dehestani²,

Doolen³

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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Combinatorial methodologies were used for the synthesis and screening of mixed metal oxide heterogeneous catalysts. Primary screening at low reactant conversions at a throughput of greater than 10,000 catalyst compositions per month was performed by using simultaneous MS and photothermal def lection spectroscopy on spatially separated thick film catalysts with Ϸ200 g per catalyst prepared by using automated liquid dispensing. Secondary screening under realistic operating conditions was performed at a throughput of greater than 3,000 catalyst compositions per month on Ϸ50 mg of catalyst in an array of fixed bed microreactors with gas chromatograph detection. The approach was validated by the discovery of catalysts with superior performance to those previously described for the oxidative dehydrogenation of ethane to ethylene. We show the full implementation and integration of combinatorial methodologies for synthesis, screening, discovery, and optimization of multicomponent heterogeneous catalysts.Although combinatorial methodologies are practiced routinely for drug discovery (1, 2), this general approach is compelling in other fields where predictive abilities also are restricted. Recently, combinatorial methods have been applied within several different areas of materials science, where increasing compositional or structural complexity often results in unique or otherwise improved properties (1-12). Structural and compositional complexity may result in systems consisting of several components functioning cooperatively. In these combinations, the synergy of the multicomponent system results in performance characteristics that are particularly difficult to predict à priori. Presently, the vast majority of complex inorganic solids and multicomponent materials remain unexplored (13), in part because composition-structure-property relationships for such systems are limited. The utility of combinatorial chemistry, i.e., the ability both to prepare and to screen vast numbers of compounds in a rapid fashion, may be most productively realized within such systems. Here, we describe an integrated combinatorial program that has resulted in the discovery of improved multicomponent heterogeneous catalysts for the oxidative dehydrogenation of ethane to ethylene. Bringing combinatorial methodologies to bear on this application is particularly appealing because catalyst discovery has relied traditionally on an iterative trial-and-error synthesis and characterization strategy that is both tedious and time consuming.The parallel synthesis of catalytic materials by the use of automation and miniaturization techniques is most efficient when preparing very small quantities (Ͻ1 mg) of catalysts. The characterization of such small amounts of catalytic materials frequently is hindered by the lack of sensitive high throughput screening methodologies, particularly for reactions of low probability such as the partial oxidation of hydrocarbons. These obstacles have been overcome in our laboratories, and an integrated combinatorial d...

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Infrared Thermographic Screening of Combinatorial Libraries of Heterogeneous Catalysts

Cited by 212 publications

References 5 publications

Combinatorial discovery of bifunctional oxygen reduction — water oxidation electrocatalysts for regenerative fuel cells

Combinatorial discovery of bifunctional oxygen reduction — water oxidation electrocatalysts for regenerative fuel cells

Química combinatória de materiais com análise por microdifração de raios X. Primeira parte: fundamentos

Combinatorial discovery of oxidative dehydrogenation catalysts within the Mo-V-Nb-O system

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