Infrasound a new weapon in cancer therapy?

Vahl, J M; Witzleben, Adrian von; Reiter, Rudolf; Theodoraki, MN; Wigand, M. E.; Hoffmann, TK; Goldberg‐Bockhorn, Eva

doi:10.1016/j.explore.2021.03.001

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Pulses with a frequency lower than 20 Hz (infrasound) can improve the effectiveness of cancer treatment—the mechanism of infrasound on cancer is based on the permeabilization of the cell membrane and sensitization to chemotherapy. Moreover, vibration may demonstrate different therapeutic effects without chemotherapy and depend on the cancer cell type, vibration frequency and time of exposure [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of 40 Hz and 100 Hz Vibration on SH-SY5Y Cells Growth and Differentiation—A Preliminary Study

et al. 2022

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(1) Background: A novel bioreactor platform of neuronal cell cultures using low-magnitude, low-frequency (LMLF) vibrational stimulation was designed to discover vibration influence and mimic the dynamic environment of the in vivo state. To better understand the impact of 40 Hz and 100 Hz vibration on cell differentiation, we join biotechnology and advanced medical technology to design the nano-vibration system. The influence of vibration on the development of nervous tissue on the selected cell line SH-SY5Y (experimental research model in Alzheimer’s and Parkinson’s) was investigated. (2) Methods: The vibration stimulation of cell differentiation and elongation of their neuritis were monitored. We measured how vibrations affect the morphology and differentiation of nerve cells in vitro. (3) Results: The highest average length of neurites was observed in response to the 40 Hz vibration on the collagen surface in the differentiating medium, but cells response did not increase with vibration frequency. Also, vibrations at a frequency of 40 Hz or 100 Hz did not affect the average density of neurites. 100 Hz vibration increased the neurites density significantly with time for cultures on collagen and non-collagen surfaces. The exposure of neuronal cells to 40 Hz and 100 Hz vibration enhanced cell differentiation. The 40 Hz vibration has the best impact on neuronal-like cell growth and differentiation. (4) Conclusions: The data demonstrated that exposure to neuronal cells to 40 Hz and 100 Hz vibration enhanced cell differentiation and proliferation. This positive impact of vibration can be used in tissue engineering and regenerative medicine. It is planned to optimize the processes and study its molecular mechanisms concerning carrying out the research.

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Section: Introductionmentioning

confidence: 99%