Industrial parks are flourishing globally and are mostly equipped with a shareable energy infrastructure, which has a long service lifetime and thus locks in greenhouse gas (GHG) emissions. We conducted a two-phase study to decarbonize Chinese industrial parks by targeting energy infrastructure. Firstly, a high-resolution geodatabase of energy infrastructure in 1604 industrial parks was established. These energy infrastructures largely featured heavy coal dependence, small capacities, cogeneration of heat and power, and were young in age. Cumulative GHG emissions, during their remaining lifetime, will reach 46.2 Gt CO 2 equivalent(eq.); comparable to the 11% of the 1.5°C global carbon budget. Secondly, a vintage stock model was developed by tailoring countermeasures for each unit and implementing a cost-benefit analysis and life cycle assessment. Total GHG mitigation potential was quantified as 8%~16% relative to the baseline scenario with positive economic benefits. The synergistic reductions in freshwater consumption, SO 2 emissions, and NO x emissions will stand at rates of 34~39%, 24%~31% and 10%~14%, respectively.