Infundibulocystic Squamous Cell Carcinoma

Kim, So Min; Kim, Hyeree; Kim, Hei Sung; Cho, Sang Hyun; Lee, Jeong Deuk

doi:10.5021/ad.2015.27.3.319

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…The cysts contained laminated or compact keratin. Misago et al described eight further such cases in 2011, with only one more similar case report thereafter [ 3 , 4 ]. Our case, being not only rare, was distinct in that no cystic structures were seen in the initial biopsy; it was not classified as an infundibulocystic SCC.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Asad¹,

Alkul²,

Shimizu³

et al. 2023

Cureus

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Squamous cell carcinoma (SCC) is a malignancy that arises from keratinocytes of the epidermis. Cystic variants of several types of cutaneous neoplasms have been rarely described in the literature. We report a case of biopsy-proven, well-differentiated invasive SCC treated with Mohs surgery. On frozen sections, the pathology slides showed benign-appearing cystic structures in the margins that persisted after it had appeared that the original malignancy had been cleared. After taking another Mohs stage due to clinical suspicion, additional SCC was found and was subsequently cleared after two more Mohs stages. To the best of our knowledge, this is the first report to histologically demonstrate biopsy-proven invasive SCC with benign-appearing cystic structures on frozen sections.

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Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Asad¹,

Alkul²,

Shimizu³

et al. 2023

Cureus

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Dermatopathology of Cutaneous Cystic Lesions: A Practical Review With Diagnostic Clues and Pitfalls

Pérez-Muñoz

Llamas‐Velasco

Castillo-Capponi

et al. 2019

The American Journal of Dermatopathology

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Background: Cystic lesions are common in the daily practice of dermatologists and dermatopathologists, and in most cases, a straightforward diagnosis can be done. Yet, some variants and situations may cause diagnostic problems or carry prognostic and/or systemic implications. Objective: To review the histopathological features of the most frequent cystic lesions, either true cysts or pseudocysts, and provide some clues and pitfalls to bear in mind for troublesome situations such as solid–cystic tumors; uncommon variants; incidental findings; artifactual, reactive, or infectious cavities; cysts as a warning of systemic and hereditary diseases; and malignant cystic tumors, either primary or metastatic. Methods: The histopathological diagnostic criteria of most cystic lesions and their potential caveats will be discussed, offering some diagnostic clues. Results: Cystic lesions of the skin can primarily be classified into true cysts and pseudocysts. The most frequent pseudocysts are sinus pilonidalis and mucin-filled cavities. True cysts can be divided according to their epithelial origin or differentiation into epidermal/pilar cysts, cysts from glandular appendages, and from embryonic remnants. Diagnostic dilemmas and possible pitfalls in cystic lesions are reviewed, offering some keys to solve them. Conclusions: Knowledge of the histopathology of cystic lesions contributes to their correct diagnosis, improving the management of patients.

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Infundibulocystic Squamous Cell Carcinoma

Cited by 2 publications

References 8 publications

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Dermatopathology of Cutaneous Cystic Lesions: A Practical Review With Diagnostic Clues and Pitfalls

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