Infusing the Chemistry Curriculum with Green Chemistry Using Real-World Examples, Web Modules, and Atom Economy in Organic Chemistry Courses

Cann, Michael C.; Dickneider, Trudy A.

doi:10.1021/ed081p977

Cited by 76 publications

(41 citation statements)

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“…The project details of many awardees are suitable for inclusion in undergraduate curricula, Table 2 lists three examples from the five 2011 winners. Other instructive real-world organic teaching examples have been described (Cann and Dickneider, 2004). Finding current green literature written at an appropriate level for instructors and students at different academic levels to digest is straightforward.…”

Section: Primary Literature ''Real-world'' Case Studiesmentioning

confidence: 99%

Green chemistry teaching in higher education: a review of effective practices

Andraos

Dicks

2012

Chem. Educ. Res. Pract.

111

122

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This account reviews published green chemistry teaching resources in print and online literature and our experiences in teaching the subject to undergraduate students. Effective practices in lecture and laboratory are highlighted and ongoing challenges are addressed, including areas in cutting edge green chemistry research that impact its teaching in the undergraduate curriculum. In particular, the influence of green chemistry on the overall teaching of organic chemistry is discussed. Challenges in teaching green chemistry 1. Examples across the chemical sub-disciplinesMost literature examples of green chemistry in the context of optimized syntheses are from an organic perspective. This includes pharmaceutically important target molecules such as sildenafil citrate (Viagrat) (Dunn et al., 2004;Dicks and Batey, 2012;Edward, 2012) and ibuprofen (Advilt) (Cann and Connelly, 2000). As such, the vast majority of green

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Section: Primary Literature ''Real-world'' Case Studiesmentioning

confidence: 99%

Green chemistry teaching in higher education: a review of effective practices

Andraos

Dicks

2012

Chem. Educ. Res. Pract.

111

122

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“…These systems are based on the 12 Principles of Green Chemistry and were redefined as the 12 Principles of Green Analytical Chemistry as outlined in Table 1 [1,5]. Green chemistry principles are now widely being incorporated into academic programs [9,10] as a means to train new scientists to consider the environmental impacts of their research. Many undergraduate and graduate programs now include curricula that apply green chemistry principles to older, more widely used chemistry techniques.…”

Section: Green Analytical Chemistrymentioning

confidence: 99%

Implementing Green Analytical Methodologies Using Solid-Phase Microextraction: A Review

2020

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Implementing green analytical methodologies has been one of the main objectives of the analytical chemistry community for the past two decades. Sample preparation and extraction procedures are two parts of analytical method development that can be best adapted to meet the principles of green analytical chemistry. The goal of transitioning to green analytical chemistry is to establish new methods that perform comparably—or superiorly—to traditional methods. The use of assessment tools to provide an objective and concise evaluation of the analytical methods’ adherence to the principles of green analytical chemistry is critical to achieving this goal. In this review, we describe various sample preparation and extraction methods that can be used to increase the greenness of a given analytical method. We gave special emphasis to modern microextraction technologies and their important contributions to the development of new green analytical methods. Several manuscripts in which the greenness of a solid-phase microextraction (SPME) technique was compared to other sample preparation strategies using the Green Analytical Procedure Index (GAPI), a green assessment tool, were reviewed.

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“…Some additional features of the BHC synthesis include easier separation procedures as well as the recovery and recycling of all catalysts. Since 1997, the BHC ibuprofen process has appeared in numerous reviews and pedagogical articles as an excellent example that highlights the benefits of catalytic reactions and their ability to improve the intrinsic efficiency of chemical processes [5,6,30,39,40].…”

Section: Ohmentioning

confidence: 99%

Green Chemistry and Associated Metrics

Dicks

Hent

2014

SpringerBriefs in Molecular Science

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This chapter provides an overview of green metrics and their historical role in promoting the development of green chemistry. Starting with the history of the field, the Twelve Principles of Green Chemistry are introduced and discussed in conjunction with a "green-by-design" approach recently applied to the synthesis of Lipitor ® . Various perspectives on synthetic efficiency are briefly outlined with reference to atom economy and E factor. These ideas are further explored in the context of three industrial processes which have received Presidential Green Chemistry Challenge Awards. The synthesis of ibuprofen is examined from the point of view of intrinsic efficiency. Using the BHC process as an example, several benefits associated with the use of catalysis are discussed, with an emphasis placed on designing atom-efficient reactions. A global perspective centered around the production of chemical waste is also outlined with reference to Merck's commercial synthesis of Januvia ® , a medication for the treatment of type II diabetes. Finally, Pfizer's new sertraline process is used to describe ways of improving both quantitative as well as qualitative aspects of an industrial synthesis. The chapter concludes with a brief outline of the future directions of green metrics.

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Infusing the Chemistry Curriculum with Green Chemistry Using Real-World Examples, Web Modules, and Atom Economy in Organic Chemistry Courses

Cited by 76 publications

References 1 publication

Green chemistry teaching in higher education: a review of effective practices

Green chemistry teaching in higher education: a review of effective practices

Implementing Green Analytical Methodologies Using Solid-Phase Microextraction: A Review

Green Chemistry and Associated Metrics

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