Infusion of nifedipine after coronary artery bypass grafting decreases the incidence of early postoperative myocardial ischemia

Seitelberger, Rainald; Zwölfer, W.; Binder, Thomas; Huber, Sebastian; Peschl, F; Spatt, J.; Schwarzacher, Severin P.; Holzinger, Christoph; Coraim, F.; Weber, Heinz; Wolner, Ernst

doi:10.1016/0003-4975(90)90357-c

Cited by 26 publications

(8 citation statements)

References 24 publications

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“…Previous studies have shown Lecaniodiscus cupanioides to possess antidepressant and anticonvulsant activities (Yemitan and Adeyemi, 2005); however the presence of mild to moderate cerebral edema even at therapeutic dose in this study suggests that the extract may be toxic with prolonged use. The presence of edema at all the doses suggests the extract may cause disturbance of microcirculation within the brain (Seitelberger et al, 1990).…”

Section: Discussionmentioning

confidence: 97%

Effects of ethanolic dried leaf extract of Lecaniodiscus cupanioides on antioxidant enzymes and biochemical parameters in rats

Oladimeji-Salami

Akindele

Adeyemi

2014

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 97%

Effects of ethanolic dried leaf extract of Lecaniodiscus cupanioides on antioxidant enzymes and biochemical parameters in rats

Oladimeji-Salami

Akindele

Adeyemi

2014

Journal of Ethnopharmacology

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“…Suffi cient coronary flow can guarantee a better flow in the subendocardium [26,27]. Several clinical and experimental investigations showed the beneficial effects of coronary dila tion in the perioperative period minimizing the perioperative ischemic damage [15,16,26,27],…”

Section: Discussionmentioning

confidence: 99%

“…Boldt et al [12,13] and Mikulasch et al [14] already reported on the beneficial effects in coronary heart disease and in weaning from cardiopulmonary bypass. In the daily routine weaning from cardiopulmo nary bypass is done using vasodilators such as nitroprusside, nitroglycerine and calcium antagonists such as nifedipine [15,16], In some cases catecholamines in combination with PDE inhibitors help patients with a low cardiac output state [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Postischemic Hemodynamic Changes after Piroximone Administration in Isolated Rabbit Heart

Zwölfer

Podesser²,

Wollenek³

et al. 1994

Eur Surg Res

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In an experimental study on 22 adult Elco rabbits, hemodynamic parameters were investigated using a working heart model. The study group (10 rabbit hearts) received 1 mg/kg i.v. of the phosphodiesterase inhibitor piroximone 15 min before thoracotomy. 12 untreated rabbit hearts served as a control group. Hemodynamic parameters were measured before and after 60 min of hypothermic ischemia. The pre-ischemic period showed no significant differences between the two groups, except the higher levels of coronary flow in the piroximone group. The postischemic period showed significant increases in heart rate, coronary flow, aortic flow and cardiac output in the piroximone group in comparison to the control group. These results indicate as a main effect the positive influence of piroximone on coronary flow, given as a single shot 15 min preoperatively. This study provides evidence of the vasodilative properties on the coronary arteries beside the documented effects on the periphery. Therefore, piroximone represents an alternative tool in weaning from the cardiopulmonary bypass.

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“…The incidence and ex tent of cardiac arrhythmias were not influ enced by nifedipine as compared to a control group receiving nitroglycerin (NTG) [5,6].…”

Section: Introductionmentioning

confidence: 99%

Postoperative Antiarrhythmic Effects of Diltiazem in Patients Undergoing Coronary Bypass Grafting

Elsadek¹,

Krause²

1994

Cardiology

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Hemodynamic problems resulting from cardiac arrhythmias often occur in patients undergoing coronary bypass grafting in the early postoperative period. Therefore, in this study the antiarrhythmic effects of the calcium channel antagonist diltiazem were evaluated in coronary bypass grafting. Forty patients were randomly assigned either to a therapy with diltiazem or nitroglycerin. Hemodynamic measurements were established by Swan-Ganz catheter, and long-term ECG analyses were performed preoperatively and 1, 3 and 5 days after operation. There were significantly fewer ventricular arrhythmias (Lown class IV) in the diltiazem groups than in the nitroglycerin groups (p < 0.05). Supraventricular tachycardias were significantly more often observed in the nitroglycerin groups on all 3 days (p < 0.05). As a result, the calcium channel antagonist diltiazem is recommended as a standard adjunct to perioperative medication in cardiac surgery.

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Infusion of nifedipine after coronary artery bypass grafting decreases the incidence of early postoperative myocardial ischemia

Cited by 26 publications

References 24 publications

Effects of ethanolic dried leaf extract of Lecaniodiscus cupanioides on antioxidant enzymes and biochemical parameters in rats

Effects of ethanolic dried leaf extract of Lecaniodiscus cupanioides on antioxidant enzymes and biochemical parameters in rats

Postischemic Hemodynamic Changes after Piroximone Administration in Isolated Rabbit Heart

Postoperative Antiarrhythmic Effects of Diltiazem in Patients Undergoing Coronary Bypass Grafting

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