Infusion of Pituitary Adenylate Cyclase–Activating Polypeptide-38 in Patients with Rosacea Induces Flushing and Facial Edema that Can Be Attenuated by Sumatriptan

Wienholtz, Nita Katarina Frifelt; Christensen, Casper Emil; Coskun, Hande; Zhang, Ditte Georgina; Egeberg, Alexander; Thyssen, Jacob P.; Ashina, Messoud

doi:10.1016/j.jid.2021.02.002

Cited by 20 publications

(13 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(5) Swelling of the maxillofacial region is closely associated with the onset of inflammation. Furthermore, facial swelling is observed in chronic angioneurotic edema ( 22 ), which is mainly due to capillary dilation, congestion, and exudation in deep connective tissue, and it is accompanied by inflammatory cell infiltration ( 23 ). Conversely, the tissues of the eyelids, upper and lower lips, and cheeks are relatively loose and are easily observed when edema occurs.…”

Section: Discussionmentioning

confidence: 99%

Development of a Method for Quantitative Evaluation of Facial Swelling in a Rat Model of Cerebral Ischemia by Facial Image Processing

Liu

Huang²,

et al. 2022

Front. Med.

View full text Add to dashboard Cite

A quantitative method for the evaluation of facial swelling in rats with middle cerebral artery occlusion (MCAO) was established using a mathematical method for the first time. The rat model of MCAO was established via bilateral common carotid artery ligation. Three groups of rats with the same baseline were selected (model group, positive drug group, and control group) according to their behavioral score and body weight 24 h after surgery. Drug administration was initiated on post-MCAO day 8 and was continued for 28 days. Mobile phones were used to collect facial images at different time points after surgery. In facial image analysis, the outer canthi of both eyes were used as the facial dividing line, and the outer edge of the rat's face was framed using the marking method, and the framed part was regarded as the facial area (S) of the rats. The histogram created with Photoshop CS5 was used to measure the face area in pixels. The distance between the outer canthi of both eyes (Le) and vertical line from the tip of the nose to the line joining the eyes was recorded as H1, and the line from the tip of the nose to the midpoint of the line joining the eyes was recorded as H2. The facial area was calibrated based on the relationship between H1 and H2. The distance between the eyes was inversely proportional to the distance between the rats and mobile phone such that the face area was calibrated by unifying Le. The size of Le between the eyes was inversely proportional to the distance between the rats and mobile phone. This was used to calibrate the face area. When compared with the control group, the facial area of the model group gradually increased from postoperative day 1 to day 7, and there was a significant difference in the facial area of the model group on postoperative day 7. Hence, positive drugs exhibited the effect of improving facial swelling. H1 and H2 can reflect the state of turning the head and raising the head of the rats, respectively. Facial area was calibrated according to the relationship between H1 and H2, which had no obvious effect on the overall conclusion. Furthermore, mobile phone lens was used to capture the picture of rat face, and the distance between the eyes and H1 and H2 was used to calibrate the facial area. Hence, this method is convenient and can be used to evaluate subjective judgment of the human eyes via a quantitative method.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of a Method for Quantitative Evaluation of Facial Swelling in a Rat Model of Cerebral Ischemia by Facial Image Processing

Liu

Huang²,

et al. 2022

Front. Med.

View full text Add to dashboard Cite

show abstract

“…A total of 35/38 patients (median 27 years, 30 females) with ETR completed the study with three lost to follow up. Compared with saline, sumatriptan significantly reduced PACAP‐38 induced facial vascular flow as measured by laser speckle contrast imaging ( p = .023), reduced superficial temporal artery dilation ( p = .01), decreased facial edema ( p < .001), and flushing duration ( p = .001) 7 . Of practical importance for dermatologists, is that while this study was conducted using intravenous sumatriptan, oral and intranasal options are commercially available.…”

Section: Diagnosis and Classificationmentioning

confidence: 96%

“…(for details, refer to section in “Persistent Erythema”). In an RCT where PACAP‐38 induced facial vascular flow, intravenous sumatriptan compared with saline significantly reduced flushing duration ( p = .001) 7 …”

Section: Diagnosis and Classificationmentioning

confidence: 99%

See 1 more Smart Citation

Rosacea treatments: Current standards and additional options

Tan

Singh

Song

et al. 2021

Dermatological Reviews

View full text Add to dashboard Cite

Background Rosacea, a chronic facial and ocular inflammatory disease, is readily visible with consequential adverse psychosocial impacts. Progress in epidemiology, pathophysiology, treatments, psychosocial and quality of life impact has led to improved outcomes. Additionally, there has been a transition to updated clinical criteria for diagnosis and classification, the phenotype approach, based on rosacea‐associated features. Objective Our objective was to identify current evidence‐based standards of treatment for rosacea highlighting recently approved interventions and including innovative options. Methods Reviews establishing current standards of care published over the past three years and English language clinical studies of rosacea treatment from 2018‐ March 2021 were included. In addition to pivotal trials, the latter were also selected based on innovation and practicality of the intervention. Results In addition to treatments identified in guidelines and systematic reviews, additional options derive from use in other dermatological conditions ‐ such as botulinum toxin, hydroxychloroquine, photodynamic therapy, radiofrequency with or without microneedling ‐ or from other medical conditions, such as artemether and sumatriptan. Conclusion We provide a template of longitudinal care for rosacea based on features divided into current standards and additional options. The latter may provide the impetus for further research and development to provide options with greater efficacy, longer remissions and/or lower risk of adverse events to improve outcomes in patients with rosacea.

show abstract

“…On the surface of keratinocytes there are neuropeptide receptors (neurokinin-1 or NK-1R for SP and RAMP-1 for CGRP). Binding of neurotransmitters to receptors stimulates keratinocytes, which causes activation of numerous proinflammatory cytokines such as: interleukin 1α and 1β (IL-1α and IL-1β), IL-8, TNF and prostaglandins E2 and F2 [22]. Stimuli such as heat, cold, spices, or capsaicin and cosmetic ingredients, especially formaldehyde, can stimulate the TRPV1 receptor.…”

Section: Zapalenie Neurogenne I Dysregulacja Układu Nerwowo-naczyniowegomentioning

confidence: 99%

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

Woźniacka¹,

Czuwara²,

Krasowska³

et al. 2022

View full text Add to dashboard Cite

EPIDEMIOLOGyRosacea is diagnosed on the basis of morphological criteria, hence there is a view that the reported incidence of the disease is lower than the actual one, especially in the case of its mild course or in people with a high skin phototype. However, it is not a rare disease, as it affects about 5% of the world's population. There is controversy in the literature regarding the prevalence of rosacea among men and women. Some authors indicate that the incidence of the disease is similar, while others emphasize that it affects women more often. Rosacea is usually diagnosed in adults between 30 and 50 years of age. Most often the disease occurs in people with fair skin, living in the northwestern part of Europe, mainly Irish, Scots and Celts with I or II skin phototype, or their relatives. It should be emphasized, however, that in about 10% of EPIDEMIOLOGIA Trądzik różowaty rozpoznawany jest na podstawie kryteriów morfologicznych, dlatego też istnieje pogląd, że raportowana częstość występowania choroby jest niższa od rzeczywistej, zwłaszcza w przypadku jej łagodnego przebiegu lub u osób z wysokim fototypem skóry. Nie jest to jednak choroba rzadka, ponieważ dotyczy około 5% osób na świecie. W piśmiennictwie istnieją kontrowersje dotyczące częstości występowania rosacea wśród mężczyzn i kobiet. Część autorów wskazuje, że częstość występowania choroby jest podobna, inni podkreślają, że częściej dotyczy kobiet. Trądzik różowaty rozpoznawany jest zwykle u osób dorosłych, pomiędzy 30. a 50. rokiem życia. W większości występuje u ludzi z niskim fototypem, zamieszkujących północno-zachodnie krańce Europy, głównie Irlandczyków, Szkotów i Celtów

show abstract

Infusion of Pituitary Adenylate Cyclase–Activating Polypeptide-38 in Patients with Rosacea Induces Flushing and Facial Edema that Can Be Attenuated by Sumatriptan

Cited by 20 publications

References 63 publications

Development of a Method for Quantitative Evaluation of Facial Swelling in a Rat Model of Cerebral Ischemia by Facial Image Processing

Development of a Method for Quantitative Evaluation of Facial Swelling in a Rat Model of Cerebral Ischemia by Facial Image Processing

Rosacea treatments: Current standards and additional options

Rosacea. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 1. Epidemiology, classification and clinical presentation

Contact Info

Product

Resources

About