Infusion of porcine plasmin in man. Studies on toxicology and pharmacodynamics

Abstract

1. Toxicity and side effects in man. 2. Immunological consequences. 3. Changes in hemostatic balance. 4. Possible simplification of the laboratory control during plasmin therapy. MATERIALS AND METHODS The observations reported in this communication were made on 6 hospitalized patients suffering from advanced cancer (metastases). Five had uniform treatment with plasmin alone, while one (Case 5) had another 4 infusions of plasmin plus 179 Scand J Clin Lab Invest Downloaded from informahealthcare.com by McMaster University on 12/01/14 For personal use only.

Effect of aprotinin on the rectal delivery of insulin

“…Aprotinin is a polypeptide of 58 amino acids obtained from the lungs or parotid glands. Because of its broad spectrum of protease inhibition, aprotinin has been clinically used in the treatment of chronic urticaria (Berova et a1 1974) and other disorders associated with increased protease activity (Franceschini 1970; Amris & Scand 1966). Aprotinin has recently been shown to enhance the absorption of a number of polypeptide hormones (Parsons et al 1979; Philippe et a1 1979) including insulin (Freidenberg et a1 1981) when administered with these compounds either subcutaneously or intramuscularly.…”

Pharmacological Induction of Fibrinolytic Activity in the Dog.

“…Activation of the fibrinolytic system with the aim of inducing thrombolysis can be produced in man by intravenous injection of exogenous material such as activator-free plasmin ( 1 ) or plasminogen activators, streptokinase and urokinase( 2 ) . The use of the body's own activators for thrombolysis has been poorly explored, though it has been repeatedly demonstrated that a variety of stimuli including pharmacological agents induce in man a marked rise of fibrinolytic activity.…”