Infusion requirements and reversibility of rocuronium at the corrugator supercilii and adductor pollicis muscles

Abstract

A larger rocuronium infusion dose was required to maintain a constant neuromuscular block at the CSM. Neostigmine-mediated reversal was faster at the CSM.

Sensitivity to Rocuronium-Induced Neuromuscular Block and Reversibility with Sugammadex in a Patient with Myotonic Dystrophy

“…The time from administration of rocuronium 1 mg/kg until T1 spontaneously reached 10% of the control value was markedly longer in our patient as compared to patients with normal neuromuscular function (70 min [7]). The time taken for T1 to reach 10% in our patient (112 min) was measured during intravenous anesthesia using propofol and remifentanil, while the previous data was observed during anesthesia with sevoflurane [7], which is known to significantly prolong the duration of action of rocuronium to 1.5–2 times [8, 9]. Assuming that the values observed in the other study were potentiated by sevoflurane, the time from administration of rocuronium 1 mg/kg to the recovery of T1 to 10% of the control level observed in our MD patient seems to have been roughly doubled.…”

Effectiveness of the timing principle with high-dose rocuronium during rapid sequence induction with lidocaine, remifentanil and propofol

“…The timing principle with rapid-onset rocuronium, on the other hand, enables the induction of general anesthesia shortly after an injection of rocuronium without the need to observe the patient's reaction. When higher-dose rocuronium is administered, the lag before detectable twitch depression is shortened to only about 30 s [18]. It is therefore recommended that hypnotic drugs should be injected 15-20 s after the administration of rocuronium, as done in the present study, to prevent patient discomfort.…”

The adequate rocuronium dose required for complete block of the adductor muscles of the thigh

“…This study is the first to investigate the response of the adductor muscles of the thigh to rocuronium. Many previous studies have reported differing responses of various muscles to rocuronium . The response to rocuronium is also known to vary between individual patients, and many factors (such as age, sex, body mass index, race, etc.)…”